肾上腺素能神经递质对人甲状腺细胞生长的影响  

Effect of adrenergic neurotransmitters on growth of cultured human thyroid cells

作　　者：刘翠萍 刘超[1] 覃又文 段宇 武晓泓 狄福松 蒋须勤 

机构地区：[1]南京医科大学第一附属医院内分泌研究室,210029

出　　处：《江苏医药》2000年第3期172-173,共2页Jiangsu Medical Journal

摘　　要：目的　研究肾上腺素能神经递质在甲状腺生长功能调控中的作用和意义。方法　选取人甲状腺腺瘤旁正常组织 ,以细胞单层培养技术和非同位素标记的细胞增殖分析法 ,检测肾上腺素和去甲肾上腺素对甲状腺细胞生长的影响。结果　肾上腺素对甲状腺细胞的增殖功能无明显影响 ,而去甲肾上腺素能够显著促进体外培养甲状腺细胞的生长作用。结论　肾上腺素能神经递质在甲状腺功能的调节中扮演重要角色。Objective To investigate the effect of adrenergic neurotransmitters on the growth function of thyroid gland.Methods Cell Titer 96 Non radioactive Cell Proliferation Assay was used to study the growth of cultured thyrocytes from paraadenomatous thyroid tissues in response to various concentrations of epinephrine and norepinephrine.Results Norepinephrine could significantly stimulate thyroid cell growth,while epinephrine had no effect on the growth of cultured thyrocytes.Conclusion Adrenergic neurotransmitters play an important role in the regulation of thyroid functions.

关 键 词：甲状腺 细胞培养 生长 肾上腺素能 神经递质 

分 类 号：R335.2[医药卫生—人体生理学]