汉防己甲素对尘肺病患者疗效探究  

Therapeutic effect of Tetrandrine on patients with pneumoconiosis

作　　者：陈子平[1] 宿文革[1] 闫永健[1] 

机构地区：[1]泰山医学院附属莱钢医院职业病科,山东莱芜271104

出　　处：《临床肺科杂志》2012年第7期1226-1227,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探究汉防己甲素对尘肺病患者的疗效。方法选择62例中重度肺功能损伤的尘肺合并感染患者随机分为对照组和实验组,两组戒烟、氧疗、营养支持、肺功能康复等基础治疗措施相同。对照组给予常规基础治疗(抗感染、止咳化痰平喘);实验组在上述常规治疗的基础上给予汉防己甲素口服治疗,单疗程3个月,设计疗程12个月。结果实验组患者治疗3个月后肺功能与对照组比较有明显差异;实验组患者12个月后肺功能虽下降,但下降速率较对照组减慢;实验组急性加重次数较对照组减少;实验组患者痰液中IL-1、TNF-α水平明显低于对照组,有显著性差异。结论在常规疗法的基础上联用汉防己甲素治疗尘肺病,早期可明显改善尘肺患者肺功能,长期可降低肺功能下降速率,减少尘肺病急性感染加重次数,减少患者痰液中免疫调节因子IL-1、TNF-α的含量。Objective To explore the therapeutic effect of tetrandrine on patients with pneumoconiosis. Methods 62 patients with moderate to severe lung injury with pneumoconiosis complicated with infection were selected and randomly divided into control and experimental groups. The basic treatment in two groups included smoking cessation, oxygen therapy, nutritional support, pulmonary rehabili- tation. The control group received the conventional therapy （antibiotics, relieving cough, dissipating phlegm and relieving asthma） ; and the experimental group received oral administration of tetrandrine hormone therapy based on the conventional treatment, single 3 months and the design course of treatment for 12 months. Lung function, the number of acute exacerbation and sputum IL-1, TNF-a levels were observed and compared between two groups. Results There was significant difference in lung function between the control group and the experimental group after 3 months treatment. Although lung function in the experimental group after 12 months treatment decreased, the rate of decrease slowed down compared with the control group. The number of acute exacerbation in experimental group was less than that in control group. Sputum IL-1, TNF-a levels in experimental group was less than those in control group, with significant differences. Conclusion On the basis of conventional therapy, tetrandrine can significantly improve lung function of patients with pneumoconiosis in pro- phase, decline the lung function rate of decrease in the long term, decrease the number of acute infection of pneumoconiosis and immune regulatory factors levels in sputum including IL-1, TNF-a.

关 键 词：汉防己甲素 尘肺病 肺功能 白介素-1 肿瘤坏死因子-Α 

分 类 号：R563.9[医药卫生—呼吸系统]