盐酸丁咯地尔对家兔全血粘度、血小板聚集和红细胞压积的影响  

Effects of buflomedil on blood viscosity platelet aggregation and haemetocrit

作　　者：杜宁[1] 杨平[2] 戴德哉[2] 严汉英[3] 

机构地区：[1]江苏省药品检验所,南京210008 [2]中国药科大学药理研究室,南京210009 [3]江苏省药物研究所,南京210008

出　　处：《中国现代应用药学》2000年第1期1-3,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的:研究盐酸丁咯地尔对血液流变学的影响。方法:测定盐酸丁咯地尔静脉给药对全血粘度、血小板聚集率和红细胞压积的影响。结果:盐酸丁咯地尔10mg/kg组可使全血粘度在高切变率80S-1时下降了17.1%,在低切变率时下降21.9%,血小板最大聚集率下降了28.2%。结论:盐酸丁咯地尔能有效地改善血液流变指标。OBJECTIVE :Theeffectsofbuflomedilonhemorrheologywasstudied .METHOD :Wecomparedthechange ofbloodViscosity ,plateletaggregation ,haematocritbeforeandaftertreatmentwithdrugs.RESULTS :Buflomedilreduced bloodviscosityobviously ,1 7.1 %inhighshearrate( 80S- 1)and 2 1 .9%inlowshearrate( 2 0S- 1) .Italsoinhibitedplatelet aggregation,themaximumADP inducedplateletaggregationwasreducedby 2 8.2 % .CONCLUSION :Theseresults suggestedbuflmedilwasaneffectiveagenttoimprovehemorrheology.

关 键 词：盐酸丁咯地尔 血液变学 全血粘度 血小板聚集 

分 类 号：R972[医药卫生—药品]