林可霉素A分子印迹聚合物微球的制备及性能  

Preparation and properties of lincomycin A molecular imprinted polymer microspheres

作　　者：蒋兴娜[1] 李卫朋[1] 张佑红[1] 朱雄伟[1] 谌颉[1] 苏腾甲[1] 

机构地区：[1]武汉工程大学化工与制药学院,绿色化工过程省部共建教育部重点实验室,湖北武汉430074

出　　处：《武汉工程大学学报》2012年第5期16-19,共4页Journal of Wuhan Institute of Technology

基　　金：武汉工程大学研究生创新项目(CX201114)

摘　　要：为提高林可霉素粗品中A组分的纯度,研究了制备林可霉素A分子印迹聚合物微球的方法及其性能.以聚苯乙烯微球为种球,林可霉素A为模板分子,通过单步溶胀法合成分子印迹聚合物微球;通过静态平衡结合法研究该聚合物的结合特性和分子识别性能.结果表明:分子印迹聚合物对模板分子具有选择性和识别能力,对林可霉素A和林可霉素B的分离因子α为1.27,而非印迹聚合物微球的分离因子α仅为1.02;林可霉素A分子印迹聚合物微球可用于制备林可霉素,并提高其粗品的纯度.To improve the purity of lincomycin A in the crude product,preparation and properties of lincomycin A molecular imprinted polymer microspheres（MIPMs） were studied.Using polystyrene particles as seeds,lincomycin as template molecules,MIPMs were prepared by a single-step swelling and polymerization method.The binding characteristics and molecular recognition of MIPMs were investigated through binding experiments.The results show the MIPMs have the selectivity for lincomycin A,the separation factor between lincomycin A and lincomycin B is 1.27,while the factor is only 1.02 by the non imprinted polymer microspheres（NIPMs）.The lincomycin A MIPMs can be used to prepare lincomycin and improve the purity of the crude lincomycin.

关 键 词：单步溶胀聚合 林可霉素 分子印迹聚合物微球 分子识别 

分 类 号：TQ317[化学工程—高聚物工业]