与学习记忆相关的脑内cGMP的表达及其与一氧化氮的关系  

Learning and memory-related expression of cGMP in rat brain and the involvement of nitric oxide

作　　者：张世仪[1] 陈纪君[1] 王松岩[1] 袁勃[1] 

机构地区：[1]中国医学科学院基础医学研究所中同阶和医科大学基础医学院,北京100005

出　　处：《基础医学与临床》2000年第1期60-62,共3页Basic and Clinical Medicine

基　　金：国家自然科学基金!39870273

摘　　要：学习记忆;;ｃＧＭＰ;;一氧化氮合酶抑制剂;;免疫组织化学;;Behavioral test and immnohistochemistry methods were used in present study. Results demonstrated, for the first time, that after a spatial alternation or active avoidance training, cGMP positive reaction increased obviously in frontal cortex and hippocampus of rats. These areas were corresponded with those of up-regulation of NOS neurons, which we reported previously. But cGMP positive reaction and NADPH-d labeling were not found in the same cell. Administration of L-NAME (70mg/kg i.p)prior to training induced performence deficit of rats in a active avoidance task. Meanwhile expression of cGMP in frontal cortex and hippocampus significantly declined. Results suggest that nitric oxide/cGMP signal pathway may be involved in normal learning and memory process.

关 键 词：学习记忆 CGMP NOS抑制剂 免疫组织化学 

分 类 号：R338.64[医药卫生—人体生理学]