体外治疗性超声促进顿抑心肌功能恢复的实验研究  

Study on External Therapeutic Ultrasound Promoting the Functional Recovery of Canine Stunned Myocardium

作　　者：邵志丽[1] 沈学东[1] 虞敏[1] 姚瑞明[1] 程蕾蕾[1] 朱哲蓓[1] 陈彤箴 张鹏[1] 陈灏珠[1] 

机构地区：[1]上海医科大学中山医院,上海市心血管病研究所200032

出　　处：《中国超声医学杂志》2000年第2期81-84,共4页Chinese Journal of Ultrasound in Medicine

基　　金：上海市医学领先专业重点学科!(94-111-001)

摘　　要：目的： 探索体外治疗性超声（ＥＴＵＳ） 促进犬顿抑心肌功能恢复的价值。方法： 将１２条犬顿抑心肌模型随机分为两组， 每组６条。治疗组在顿抑心肌模型建立后即用ＥＴＵＳ（强度１．２Ｗ／ｃｍ ２ ， 频率０．８ＭＨｚ） 治疗３０分钟； 对照组不作任何处理。取乳头肌水平短轴切面用彩色室壁运动分析（ＣＫ） 观察治疗组和对照组各１０个顿抑心肌节段冠脉松解后０～１５０ｍ ｉｎ 室壁运动， 每隔１５ｍ ｉｎ 观察一次。并以黄色带宽度代表室壁运动强度， 比较两组冠脉松解后０ｍ ｉｎ～１５０ｍ ｉｎ 室壁运动变化差值和趋势；还比较两组室壁运动改善１级所用的时间。最后取缺血区及非缺血区心肌标本作病理。结果： 治疗组和对照组冠脉松解后１５０ｍ ｉｎ 与０ｍ ｉｎ 的室壁运动强度平均差值分别为０．１５９±０．０５３ｃｍ 和０．０９９±０．０７ｃｍ ， 前者显著大于后者（Ｐ＜ ０．０５）。各节段点图中的点经相关系数ｔ检验符合直线分布， 故可用回归直线的斜率表示室壁运动随时间的变化率。治疗组平均斜率显著大于对照组（０．００１２５±０．０００６２ 和０．０００６１±０．０００３８ｃｍ ／ｍ ｉｎ， Ｐ＜ ０．０５）。治疗组和对照组室壁运动改善１级所用的时间分别为６７．５±?Objective:To evaluate the external therapeutic ultrasound(ETUS)in promoting the functional recovery of stunned myocardium.Methods:12 canine stunned myocardium models were randomly divided into two groups:the therapy group(6 dogs)was treated by ETUS for 30 minutes at 1 2w/cm 2 and 0 8MHz.The control group(6 dogs)was not treated.10 segments of stunned myocardium in every group were studied by colour kinesis(CK)at left ventricular short axis view on the level of papillary muscle to determine the wall motion from the beginning of stunned myocardium models set up until 150 minutes(every 15 minutes per time).The width of yellow colour overlay represented the amplitude of wall motion.The alteration and trends of segmental wall motion in two groups were compared.The time duration between the onset to wall motion improving one grade was assessed.The myocardium of the stunned and non stunned area was taken for pathological examination.Results:The difference of the width of yellow colour overlay between 0 min and 150min after relax of coronary ligation in therapy group showed a significantly greater than the control group(0 159±0 053cm vs.0 099±0 07cm, P <0 05).There was linear relationship between the amplitude of wall motion and time.So the slope of each regressive line for each segment could be used to represent the changeable trend of wall motion with time.The average slope in the therapy group was significantly greater than the control group(0 00125±0 00062 cm/min.vs.0 00061±0 00038 cm/min., P <0 05).The time duration from onset to wall motion improving one grade in the therapy group was shorter than the control group(67 5±34 10min vs 109 5±47 46min respectively, P <0 05).Conclusion:Our experiment showed that ETUS could promote the functional recovery of canine stunned myocardium.But the mechanism was not clear yet.

关 键 词：体外治疗性超声 顿抑心肌 心肌功能 

分 类 号：R454.3[医药卫生—治疗学]