离体大鼠皮片对雷公藤内酯醇的吸收  

Permeability of triptolide through excised rat skin in vitro

作　　者：颉江敏[1] 蒲家志[1] 马文玺[2] 刘贤荣[2] 

机构地区：[1]遵义医学院化学教研室,贵州遵义563003 [2]遵义医学院第一附属医院,贵州遵义563003

出　　处：《中国药理学与毒理学杂志》2000年第1期76-78,共3页Chinese Journal of Pharmacology and Toxicology

基　　金：:贵州省科委基金

摘　　要：作者建立了高效液相色谱法 ,适合于研究搽剂中雷公藤内酯醇的透皮吸收量 .结果表明单位面积透皮释药量与渗透时间有较好的线性关系 ,符合零级药代动力学过程 ,平均回收率为 93.5% - 98.5% ;氮酮含量为 2 .0 %时促渗透作用最好 ,此时单位时间内累积透皮吸收量为 3.5μg·cm-2 ·h-1.For investigating the permeability of triptolide in vitro through excised rat skin in the liniment of Tripterygium hypoglacum(Levl.) Hutch, a high performance liquid chromatography(HPLC) method was established. The results showed that there was a good linear correlation between the accumulative permeated amount per unit area and the time, following zero order pharmacokinetics, and the average recovery was 93.5%-98.5%(n=3). The optimum concentration of azone is 2.0% with a percutaneous rate of 3.5 μg·cm -2 ·h -1 .

关 键 词：高效液相色谱 雷公藤内酯醇 搽剂 透皮吸收 

分 类 号：R965[医药卫生—药理学]