Preparation and biocompatibility evaluation of poly(D,L-lactide-co-glycine)  

作　　者：胡耀平 曹雷健 谷俐 李清华 沈红霞 郑涛 

机构地区：[1]School of Materials Science and Engineering,Changzhou University [2]Institute of Polymer Material Engineering,Jiaxing University

出　　处：《Journal of Central South University》2012年第6期1517-1521,共5页中南大学学报（英文版）

基　　金：Project(21107032) supported by the National Natural Science Foundation of China; Projects(Y406469, Y4110606) supported by the Natural Science Foundation of Zhejiang Province, China;Projects(2008AY2018, 2011AY1048-5, 2011AY1030) supported by the Science Foundation of Jiaxing Science and Technology Bureau,China;Project(2009C21003) supported by the Science and Technology Department of Zhejiang Province,China

摘　　要：D,L-lactide was prepared from D,L-lactic acid by means of polymerization and depolymerization at low vacuum level.Morpholine-2,5-dione(MD) was synthesized from the cyclization of chloroacetyl glycine which was made from chloroacetyl chloride and glycine in the basic condition.A novel copolymer(PLAMD) with D,L-lactide(D,L-LA) and morpholine-2,5-dione(MD) was synthesized using stannous octoate as initiator,and characterized with FT-IR and 1HNMR.The biocompatibility of PLAMD and PLA was investigated by MTT and microscope.The results show that amino acid is introduced into PDLLA main chain.PLAMD has better cell affinity than PLA,so it is a promising biomaterial.D,L-lactide was prepared from D,L-lactic acid by means of polymerization and depolymerization at low vacuum level. Morpholine-2,5-dione （MD） was synthesized from the cyclization of chloroacetyl glycine which was made from chloroacetyl chloride and glycine in the basic condition. A novel copolymer （PLAMD） with D,L-lactide （D,L-LA） and morpholine-2,5-dione （MD） was synthesized using stannous octoate as initiator, and characterized with FT-IR and 1HNMR. The biocompatibility of PLAMD and PLA was investigated by MTT and microscope. The results show that amino acid is introduced into PDLLA main chain. PLAMD has better cell affinity than PLA, so it is a promising biomaterial.

关 键 词：morpholine-2 5-dione LACTIDE amino acid BIOCOMPATIBILITY 

分 类 号：O631.3[理学—高分子化学]