不同比例制川乌配伍甘草对单酯型生物碱煎出量的影响  

Effect of Aconiti Radix Preparata combined with Glycyrrhizae Radix in different ratios on monoester alkaloids

作　　者：王峰峰[1,2] 宋兆辉[2] 张兰兰[2] 周水平[2] 冯锋[1] 

机构地区：[1]中国药科大学,江苏南京210009 [2]天津天士力集团研究院中药所,天津300410

出　　处：《中草药》2012年第6期1101-1104,共4页Chinese Traditional and Herbal Drugs

基　　金："十一五"国家重大新药创制课题(2010ZX09401-406)

摘　　要：目的研究制川乌配伍甘草对制川乌中多种单酯型生物碱煎出量的影响,探索其变化规律,以指导制川乌与甘草的合理配伍。方法 HPLC法测定制川乌与甘草不同比例配伍时煎出液中单酯型生物碱的总量,并通过对比,分析不同配比对煎出量的影响。结果随着甘草配伍量的增加,煎煮液中单酯型生物碱总量逐渐降低,每种单酯型生物碱煎出量趋于单煎液煎出量的40%。结论甘草配伍制川乌时,甘草的使用量应是制川乌的一半以上,既可以保证煎出液中单酯型生物碱总量稳定可控,又可以防止制川乌毒性过大造成使用危险。Objective To study the effect of Aconiti Radix Preparata （RAP） combined with Glycyrrhizae Radix （RG） in different ratios on the deeoeted yield of monoester-type alkaloid from RAP and to investigate the disciplines of various eompatibilities. Methods HPLC was adopted to determine the monoester-type alkaloid in decoction with different ratios of RAP and RG. The influence of the various eompatibilities on alkaloid was analyzed. Results The total decoeted yields of monoester-type alkaloid in the decoetion decreased with the increasing of RG in the decoction. The monoester-type alkaloid in compatibility tended to be 20% of RAP single decoction. Conclusion The usage of RG should be more than half of that of RAP when using together, which could make the yields of monoester-type alkaloid stable and controllable and avoid the danger for use from the excessive toxicity of RAP.

关 键 词：醋商陆 商陆皂苷甲 炮制工艺 正交试验 优选 

分 类 号：R283.1[医药卫生—中药学] R286.02[医药卫生—中医学]