喷他佐辛对瑞芬太尼麻醉后痛觉过敏的影响  

Effect of pentazocine on postoperative hyperalgesia after remifentanlbased anesthesia

作　　者：王昕[1,2] 艾登斌 张继国[3] 岳旺[1] 

机构地区：[1]青岛大学医学院药学系药理室,山东青岛266021 [2]青岛市立医院麻醉科,山东青岛266000 [3]泰山医学院药理教研室,山东泰安271016

出　　处：《泰山医学院学报》2012年第2期111-113,共3页Journal of Taishan Medical College

摘　　要：目的观察喷他佐辛对预防瑞芬太尼麻醉后痛觉过敏的影响.方法选择择期行腹腔镜胆囊切除术病人60例(ASAⅠ～Ⅱ级),随机分为2组,各组均采取气管内插管全凭静脉麻醉,术中以静脉泵注丙泊酚以及瑞芬太尼维持麻醉,间断给予维库溴铵维持肌松。P组(n=30):手术结束前10min静脉滴注喷他佐辛0.5 mg/kg;F组(n=30):手术结束前10 min静脉滴注芬太尼1μg/kg。记录2组病人自主呼吸恢复时间、呼之睁眼时间、气管导管拔除时间、拔管后5 min、10 min VRS评分以及术后24h有无恶心呕吐、呼吸抑制及术后躁动情况。结果 2组患者拔管后VRS评分差异无显著性(P>0.05),自主呼吸恢复时间、呼之睁眼时间、气管导管拔除时间P组明显短于F组(P<0.05),术后24 h内2组均无呼吸抑制、恶心呕吐和躁动。结论喷他佐辛0.5 mg/kg静脉滴注可有效减轻瑞芬太尼全麻后急性痛觉过敏。Objective： To observe the effect of pentazocine on preventing postoperative hyperalgesia induced by remifentanil based anesthesia. Methods： Sixty cases of Laparoscopic Choleeystectomy, ASA 1-11 class, were randomly divided into two groups, using intravenous anesthesia and intubation, intraoperative continuous intravenous injection of propofol and remifcntanil to maintain anesthesia, and given intermittent vecuronium to maintain muscle relaxation. Patients in Group P （n = 30）received pentazocine（0.5 mg/kg） by intravenous injection at 10 minutes before the end of the operation; Patients in Group F（ n = 30） received fentanyl（ 1 μg/kg） by intravenous injection at 10 minutes before the end of the operation. The time was recorded of the resumption of apontaneous respiration, eye opening and extubation, the VRS pain score at 5 mi- nutes and 10 minutes after extubation, adverse reactions with nausea and vomiting and respiratory inhibition and dysthesia in the 24 hours after operation. Results ： There was no statistical significance in VRS pain score after extubation （ P 〉 0. 05）. The time of resumption of apontaneous respiration, eye opening and extubation in Group P was significantly shorter than that in Group F （P 〈 0.05） , and there was no adverse reactions with nausea and vomiting and respiratory inhibition and dysthesia in the 24 hours after operation. Conclusion： Pentazoeine （0.5mg/kg） by intravenous injection can release postoperative hyperalgesia induced by remifentanil based anesthesia.

关 键 词：喷他佐辛 瑞芬太尼 痛觉过敏 

分 类 号：R614.24[医药卫生—麻醉学]