重度宫腔黏连患者宫腔黏连分离术后雌激素的应用效果  

Effectiveness of estrogen treatment after transcervical resection of adhesions on severe uterine adhesion patients

作　　者：封全灵[1] 王丽平[1] 杨淑玲[2] 申爱荣[1] 白桦[2] 张凤芝[2] 

机构地区：[1]郑州大学第三附属医院妇产科,郑州450052 [2]郑州大学第三附属医院河南省妇科内镜诊治中心,郑州450052

出　　处：《郑州大学学报（医学版）》2012年第3期393-395,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨重度宫腔黏连(IUA)患者行宫腔镜宫腔黏连分离术(TCRA)后应用雌激素的疗效。方法:95例行TCRA术的重度IUA患者,术后辅以不同剂量(0.625、1.250、1.975和2.500mg/d)及疗程(用药1～3个月经周期和≥4个月经周期)雌激素治疗为观察组,20例未服用任何雌激素患者为对照组。随访2组术后月经改善情况、宫腔再黏连情况、用药不良及妊娠情况。结果:观察组与对照组的月经改善率和宫腔再黏连率差异有统计学意义(χ2=14.446和4.876,P<0.05)。不同剂量和疗程雌激素应用的月经改善率、宫腔再黏连率和妊娠率差异无统计学意义(P>0.05)。剂量和疗程对重度IUA患者术后月经改善、宫腔再黏连和妊娠无影响(P>0.05)。结论:重度IUA患者TCRA术后应用雌激素是有效预防黏连的方法;不同剂量、疗程雌激素对TCRA术后预防IUA效果相同。Aim：To explore the curative effect of different doses and different cycles of conjugated estrogen treatments on severe uterine adhesion（IUA） patients after transcervical resection of adhesions（TCRA）.Methods：A total of 95 cases who administered estrogen after TCRA and 20 cases without using estrogen after TCRA were included in the study as observation group and blank group respectively.Patients in the observation group all took conjugated estrogens postoperatively with different doses（0.625,1.250,1.975,2.500 mg/d） and different treatment cycles（1～3 and more than 4 menstrual cycles）.All patients were followed up to investigate their menstrual condition,hysteroscopy recheck result,drug side effects and pregnancy.Results：The menstrual improvement rate and intrauterine re-adhesion rate in the observation group were significantly different from those in the blank group（χ2=14.446 and 4.876,P0.05）.There was no significant difference in the menstrual condition,uterine re-adhesion rate and the pregnancy rate among patients treated with different doses of conjugated estrogen or treated for different cycles（P0.05）.Logistic regression analysis also showed that neither doses nor cycles of conjugated estrogen entered regression model（P0.05）.Conclusion：Conjugated estrogen treatment is effective to IUA patients after TCRA.Different doses and cycles of treatment with conjugated estrogen after TCRA do not affect the curative effect.

关 键 词：重度宫腔黏连 雌激素 宫腔黏连分离术 

分 类 号：R71[医药卫生—妇产科学]