以皮肤结节红斑为首发症状的51例患者临床分析  

Clinical Analysis of 51 Patients with Skin Erythema Nodosum

作　　者：曾沛英[1] 路晓燕[1] 陈晓敏[1] 

机构地区：[1]深圳市北京大学深圳医院风湿免疫科,深圳518036

出　　处：《中国医药导刊》2012年第5期751-752,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨以皮肤结节红斑为首发症状患者的病因、临床表现、治疗及预后等,以提高认识。方法:收集我院2008年11月～2011年11月因皮肤结节红斑来诊51例患者的病因、临床表现、预后等临床资料,进行统计学分析。结果:男9例(17.6%),女42例(82.4%),年龄(17～47)岁,平均(38±17)岁。病因:感染27例(53.0%),其中链球菌感染14例,结核感染13例;风湿免疫病18例(35.3%):白塞病8例,结节性多动脉炎4例,干燥综合征2例,系统性红斑狼疮1例,类风湿关节炎1例,结节病1例,变应性肉芽肿性血管炎1例;脂膜炎样T细胞淋巴瘤2例(3.9%);白色萎缩1例(2.0%);病因不明3例(5.9%)。临床表现多为双胫前皮肤结节红斑。治疗后完全消失的41例((80.4%)、色素沉着5例(9.8%)、疤痕2例(3.9%)、2例淋巴瘤及1例系统性红斑狼疮至死亡前结节红斑无好转。结论:结节红斑以感染为最多见,其次为风湿免疫病,另有少部分人为恶性肿瘤,故对于首发表现为结节红斑的患者,除常规排查感染外,应警惕风湿免疫病及恶性肿瘤,以免延误诊治。大部分患者预后良好,完全愈合,不影响美观。Objective：To investigate the causes,clinical feathers,treatment and outcomes of erythema nodosumMethods：Analysis the data of the causes,clinical feathers,treatment and outcomes of 51 patients.Results： Mate 9 female 42 cases.The common causes were infection（27 cases）： the most common are streptococcal infection and mycobacterium tuberculosis infection.18 cases were rheumatic disease.2 cases with Subcutareous Panniculitis-like T-cell Lymphoma.The most common clinical manifestations were skin erythema and nodule located on anterior shank.Most patients respnsed well to the treatment.Conclusion：The common causes were infection and rheumatic disease,and individual lymphoma.The patients with initial manifestation as erythema nodosum should be conventional investigation of infecion,and be alert to autoimmune rheumatic disease and malignant tumor,so as not to delay treatment.Most patients responsed well to the treatment,and had a good prognosis.

关 键 词：结节性红斑 感染 风湿免疫病 淋巴瘤 

分 类 号：R593.2[医药卫生—内科学]