血清胆汁酸在妊娠期肝内胆汁淤积症中的诊断价值  

The value of serum bile acid in diagnosis of intrahepatic cholestasis of pregnancy

作　　者：王晓丽[1] 李博[2] 赵彦梅[1] 王昕[1] 

机构地区：[1]山东省聊城市第二人民医院妇产科,山东临清252600 [2]山东省聊城市第二人民医院外科,山东临清252600

出　　处：《中国医师进修杂志》2012年第15期17-19,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨血清胆汁酸在妊娠期肝内胆汁淤积症（raP）诊断中的应用价值。方法对待产的92例ICP患者的临床资料进行回顾性分析，按血清胆汁酸水平将患者分为两组，血清胆汁酸〉40μmol／L为观察组（46例），血清胆汁酸≤40μmol]L为对照组（46例），观察比较两组患者皮肤瘙痒出现时间，黄疸程度，血清丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST），羊水污染程度。结果观察组皮肤瘙痒出现时间早于对照组[（29．1±3-4）周比（33．9±3．2）周，尸〈0．05]；重度黄疸、ALT〉100 U／L、AST〉100U／L及羊水Ⅲ度污染例数均多于对照组[27例比15例、28例比20例、28例比18例、23例比15例，P〈0．01或〈0．0530结论血清胆汁酸可作为评估ICP的敏感指标，对孕妇病情的判断、预后分析具有重要的意义，具有反映其发生妊娠不良结局的可能性。Objective To evaluate the application value of serum bile acid in diagnosing intrahepatic cholestasis of pregnancy （ICP）. Methods The clinical data of 92 prepartal patients with ICP was analyzed retrospectively. The patients were divided into observation group （ 〉 40 μmol/L ） and control group （ ≤40 mol/L） with 46 cases each according to serum bile acid level. The occurrence time of Skin pruritus, jaundice degree,serum alanine aminotransferase （AET）,aspartate aminotransferase （AST） and degree of polluted amniotic fluid of two groups were observed and compared. Results The occurrence of skin pruritus in observation group was earlier than that in control group [ （29.1 ± 3.4） weeks vs.（33.9 ± 3.2） weeks ,P 〈 0.05 ];the cases with severe jaundice,ALT 〉 100 U/L, AST 〉 100 U/L and amniotic fluid contamination Ill degree in observation group were more than control group [27 cases vs. 15 cases,28 cases vs. 20 cases,28 cases vs. 18 cases, 23 cases vs. 15 cases, P 〈 0.01 or 〈 0.05 ]. Conchmions Serum bile acid, as a sensitive indicator to assess TCP, has important value in determining the condition of pregnant women and prognosis analysis, and it can reflect the occurrence possibility of bad perinatal outcomes.

关 键 词：胆汁酸类和盐类 转氨酶类 肝内胆汁淤积症 妊娠 

分 类 号：R714.255[医药卫生—妇产科学]