ω-3多不饱和脂肪酸对PTSD-SPS大鼠行为学影响的研究  

Effects of w-3 Polyunsaturated Fatty Acids on Behavioral Changes of Rats with PTSD-SPS

作　　者：朱敏[1] 王彬[1] 王枫[1] 郑刚[2] 张雪平[1] 

机构地区：[1]第四军医大学军事预防医学院营养与食品卫生学教研室 [2]第四军医大学军事预防医学院劳动卫生与环境卫生学教研室,陕西西安710032

出　　处：《现代生物医学进展》2012年第12期2290-2293,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金(30972428)

摘　　要：目的:观察饲料中添加ω-3PUFAs对PTSD-SPS大鼠焦虑/抑郁行为的防护作用。方法:将40只健康成年雄性SD大鼠随机分为正常对照组、PTSD-SPS模型组、60%ω-3PUFAs+PTSD-SPS模型组1、60%ω-3PUFAs+PTSD-SPS模型组2。采用高架十字迷宫实验和旷场实验评价实验组大鼠的焦虑/抑郁行为变化。结果:与对照组相比,SPS模型组大鼠进入开放臂的次数比例和时间比例明显减少;中央格停留时间明显缩短(5.56±0.21)s,穿格次数明显减少(30.23±5.96)次,差异均显著(P<0.05)。与SPS模型组相比,60%ω-3PUFAs的SPS组大鼠进入开放臂的次数比例和时间比例明显增加;中央格停留时间明显延长(9.88±1.14)s,穿格次数明显增加(43.22±4.35)次,差异均显著(P<0.05);与对照组相比没有显著差异。结论:膳食补充ω-3多不饱和脂肪酸可以降低PTSD-SPS大鼠焦虑/抑郁程度。Objective： To investigate the effects of ω-3PUFAs on the anxiety and depression-like behaviors of rats with PTSD-SPS. Methods： Forty male SD rats were randomly and equally divided into 4 groups： control group, PTSD-SPS group, 60 % to-3PUFAs ＋ PTSD-SPS group 1, 60 % to-3PUFAs ＋ PTSD-SPS group 2. The behavioral changes were evaluated by the EPM test system and the OF test system. Results： In the EPM test, the number of entering the open-arm and the open-arm detention time in the PTSD-SPS group were significantly lower than that of the control group （P〈0.05）. The time of resting on the center lattice and times of spanning lattice in the SPS group decreased （5.56 ± 0.21） s and （30.23 ± 5.96） times in the OF test （P〈0.05）, respectively. The num- ber of entering the open-ann and the open-arm detention time in the to-3PUFAs group were significantly lower than that of the SPS group （P 〈0.05） in the EPM test. The time of resting on the center lattice and times of spanning lattice were increased （9.88 ± 1.14） s and （43.22 ± 4.35） times in the OF test （P〈0.05）, respectively. There were no significance difference between the ω-3PUFAs group and the control group. Conclusion： Dietary Supplement of ω-3PUFAs could reduce the anxiety and depression-like behaviors of PTSD-SPS model rats.

关 键 词：PTSD Ω-3多不饱和脂肪酸 高架十字迷宫实验 旷场实验 

分 类 号：Q95-33[生物学—动物学] R338.64[医药卫生—人体生理学]