特拉唑嗪联合前列癃闭通胶囊治疗慢性前列腺炎临床研究  

Clinical application of terazosin combined with Qianlielongbitong in the treatment of chronic non-bacterial prostatitis

作　　者：陈纪海[1] 顾农[1] 张国静[1] 谢非[1] 李加法 袁秋生[1] 

机构地区：[1]杭州市西湖区第二人民医院外科,浙江省杭州320024

出　　处：《中国基层医药》2012年第11期1603-1604,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：2011年浙江省杭州市卫生局科技项目（2011B043）

摘　　要：目的观察特拉唑嗪联合前列癃闭通胶囊治疗慢性非细菌性前列腺炎（NBP）的疗效。方法102例NBP患者随机分为治疗组54例和对照组48例，治疗组口服特拉唑嗪＋前列癃闭通胶囊；对照组口服特拉唑嗪＋左氧氟沙星。分别观察治疗前、治疗4周、8周后慢性前列腺炎症状指数评分（NIH—CPSI）、前列腺按摩液（EPS）常规检查及尿流率的变化。结果治疗4周后，两组NIH—CPS总评分、症状评分、生活质量评分、疼痛症状评分及排尿症状评分较治疗前均明显改善（t=14．80、16．20、6．15、8．67、10．00、16．47、14．62、8．79、10．77、10．86，均P〈0．01）；治疗8周后，对照组NIH—CPS评分较治疗4周时无明显改善（均P〉0．05），治疗组较治疗4周时有明显改善（t=2．76、2．71、2．75、2．72、2．73，均P〈0．01）。治疗4周后，两组AFR、MFR较治疗前均增加（t=11．56、11．84、13．85、12．80，均P〈0．01）；但两组问差异均无统计学意义（均P〉0．05）。结论特拉唑嗪联合前列癃闭通胶囊治疗NBP可减轻临床症状，提高生活质量。Objective To investigate the effect and mechanism of terazosin combined with Qianlielongbitong in the treatment of non-bacterial prostatitis. Methods One hundred and two patients with non-bacterial prostatitis were divided into two groups：one group was treated with terazosin 4 mg qn and Qianlielongbitong, while the other group was treated with terazosin and Levoofloxacin. We compared three indices of chronic prostatitis symptom index （NIH-CPSI）, prostatic secretion examination（EPS） and urodynamic data in three different steps：before treatment, af- ter 4-week treatment and after 8-week treatment. Results The NIH-CPSI of both groups was greatly improved after treatment （all P 〈 0.01 ）. Inside the treatment group, the NIH-CPSI after 8-week treatment was better than that after 4- week treatment（ all P 〈 0.01 ）. However, in both groups, there was no significant difference between the index after 8- week treatment and the one after 4 week. EPS, AFR and MFR were greatly improved in both groups （ all P 〈 0. 01 ）. Conclusion Terazosin can relieve the clinical symptom, and improve the life quality.

关 键 词：前列腺炎 特拉唑嗪 前列癃闭通胶囊 

分 类 号：R697.3[医药卫生—泌尿科学]