干扰素α-2b对慢性乙型肝炎患者血清干扰素诱导蛋白、活性调节蛋白水平的影响  

Relationship between the serum chemokine IP-10 and RANTES levels and Interferon therapeutic early re- sponse in patients with chronic hepatitis B

作　　者：李文莉[1] 吴茂盛[1] 黄育波[1] 朱计芬[1] 刘细玲[1] 许瑞荣[1] 

机构地区：[1]广东省第二人民医院感染科,广东省广州510317

出　　处：《中国基层医药》2012年第9期1283-1285,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：基金项目：广东省社会发展领域科技计划项目（粤科函社字[2010]1096号）

摘　　要：目的观察慢性乙型肝炎患者血清干扰素诱导蛋白（IP-10）和正常T细胞表达分泌的活性调节蛋白（RANTES）在干扰素α-2b治疗前、后的变化。方法选择50例HBeAg阳性慢性乙型肝炎患者予以普通干扰素α-2b治疗，根据治疗12周时病毒学应答情况分为完全应答A组（32例）、部分应答B组（12例）、无应答C组（6例）。Luminex液相蛋白芯片法检测三组治疗前及治疗后4周、12周血清IP-10、RANTES水平，并同时检测血清HBVDNA水平、ALT水平和HBV标志物。结果治疗前，三组问血清HBVDNA、RANTES水平差异无统计学意义（P〉0．05）；三组间ALT水平差异均有统计学意义（P〈0．05）；三组IP-10、RANTES水平均较正常对照组升高（P〈0．05）；三组间IP-10水平差异有统计学意义（P〈0．05），其中A组最高（24．05±7．68），B组次之（20．85±4．85），C组最低（11．254-5．65）；与治疗前相比，治疗4周A组血清IP-10、RANTES水平开始下降（P〈0．05），B组、C组无明显差别（P〉0．05）；治疗12周时，三组IP-10水平变化差异有统计学意义（-17．28±4．25、-8．34±1．10、＋1．68±0．22）（P〈0．05），RANTES水平变化差异有统计学意义（-38．57±3．54、-13．87±3．14、-6．65±1．79）（P〈0．05）；C组的IP-10、RANTES水平在治疗4、12周时均无统计学意义（P〉0．05）；治疗12周时，三组HBVDNA水平变化差异有统计学意义（3．91±1．13、2．62±0．52、0．98±0．80）（P〈0．05）；三组AIJT水平变化差异有统计学意义（-157．2±26．8、-39．2±11．4、＋3．7±8．9）（P〈0．05）；50例患者血清IP-10水平与ALT水平呈正相关，RANTES水平与HBVDNA水平呈正相关，治疗前IP-10水平与治疗12周时的HBVDNA下降水平呈正相关；应答组44例治疗12周的IP-10、RANTES下降水平与ALT下降水平呈正相关。结论干扰素α-2b治疗后慢性乙型肝炎患者肝脏炎症减轻，Objective To investigate the relationship between the serum chemokine IP-10 and RANTES lev- els and Interferon therapeutic early response in patients with chronic hepatitis B （CHB）. Methods 50 patients with chronic hepatitis B were chosen into interferon therapy. After 12 weeks,they were devided into three groups：complete response A,partial response B,non response C group. HBV-DNA was detected by PCR; The serum chemokines（ IP-10 and RANTES） were measured by Luminex Liquichip technology. Results The base HBV DNA and RANTES levels of three groups weren＇t significantly different （ P 〈 O. 05 ） ; The base ALT and IP-10 levels of A group were significantly higher than that in B and C group（P 〈 0. 05）. The IP-10,RANTES contents of A group in therapeutic 4th week were significantly lower than that before interferon therapy（P 〈 0. 05） ;There were no significant differences in B,C group （P 〉 0. 05） ;The levels changes of IP-10,RANTES, HBV DNA and ALT in therapeutic 12th week were significantly different between the three groups（ P 〈 0.05 ）. The level of ALT in 50 patients has positive correlation with IP-IO level （P 〈 0.05 ） ;The level of HBV DNA in 50 patients had positive correlation with RANTES level（ P 〈 0.05 ） ;The base level of IP-IO had positive correlation with the change of HBV-DNA contents in therapeutic 12th week （P 〈 0. 05 ） ; The change of ALT level in reponse patients in therapeutic 12th week had positive correlation with the change of IP- 10,RANTES levels （P 〈 0.05 ）. Conclusion The decrease of IP-10, RANTES level in CHB patients received 12 weeks interferon-or therapy could lead to reduce liver inflammation;The base IP-10 level probably was relevant to the early response in CHB patients received interferon-αtherapy.

关 键 词：肝炎 乙型慢性 干扰素Α-2B 

分 类 号：R512.62[医药卫生—内科学]