内脏脂肪素及脂蛋白相关磷脂酶A_2在动脉粥样硬化发病中的意义  

Value of Visfatin and Lipoprotein-associated Phospholipase A_2 in Atherosclerosis

作　　者：刘后光[1] 陈淑燕[1] 刘鹏 

机构地区：[1]河北联合大学心血管内科,河北唐山063000 [2]煤炭总医院心脏中心,北京100028

出　　处：《医学综述》2012年第10期1469-1471,共3页Medical Recapitulate

摘　　要：内脏脂肪素是脂肪组织分泌的重要产物,实验表明内脏脂肪素可作为一个炎性介质在动脉粥样硬化形成过程中起重要作用。脂蛋白相关磷脂酶A2是由成熟的巨噬细胞和淋巴细胞合成、分泌的,大量的基础研究和临床表明,脂蛋白相关磷脂酶A2及其水解产物参与动脉粥样硬化的形成和发展,具有致动脉粥样硬化作用。对内脏脂肪素和脂蛋白相关磷脂酶A2的研究将为探讨动脉粥样硬化性疾病的发病机制及治疗方案提供新的思路。Visfatin is an important product of the adipose tissue. The test shows that visfatin may act as an inflammatory medium playing an important role in the form ation of atherosclerosis. A lot of basic researches and clinical experiments prove that lipoprotein-associated phospholipase A2 （ Lp-PLA2 ） are synthetized and se- creted by macrophages and lymphocytes, and its hydrolysis products can cause coronary atherogensis by partici- pading in the shaping and development of atherosclerosis. The study of visfatin and Lp-PLA2 will provide new thoughts for exploring the mechanisms and treatments of the atherosclerosis diseases.

关 键 词：内脏脂肪素 脂蛋白相关磷脂酶A2 动脉粥样硬化 心血管疾病 

分 类 号：R544[医药卫生—心血管疾病]