血浆B型脑钠肽与急性心肌梗死心功能及预后的相关研究  

The relationship between plasma BNP level and myocardial function in patients with acute myocardial infarction and its value in forecasting prognosis

作　　者：蒋一鸣 杨庆业[1] 俎德玲[1] 诸葛毅[2] 屠晓鸣[1] 金奇志[1] 程科云[1] 高珍艳[1] 郑家胜[1] 

机构地区：[1]浙江省衢州市人民医院心血管内科,浙江衢州324000 [2]衢州学院,浙江衢州324000

出　　处：《中国卫生检验杂志》2012年第5期1086-1088,共3页Chinese Journal of Health Laboratory Technology

基　　金：衢州市科技局课题项目(20090327132024525)

摘　　要：目的:研究急性心肌梗死(AMI)后血浆B型脑钠肽(BNP)水平的变化及其对AMI后近期心功能不全及预后的预测价值。方法:入选100例初发急性心肌梗死患者,入院24 h内测定血浆BNP浓度、进行超声心动图检查测定左室射血分数(LVEF)、测定心肌酶谱、肌钙蛋白I定量,并记录患者心功能Killip分级等项目。所有患者观察随访4周,4周时记录观察期间死亡的发生与否。结果:①AMI后急性期血BNP与心功能Killip分级呈正相关;②死亡组BNP、Killip分级、CK-MB均显著高于存活组(P<0.01);AMI后近期死亡与急性期血BNP、CK-MB浓度及Killip分级正相关。结论:血BNP在AMI后的高危患者中显著升高,与急性期心功能Killip分级显著相关,可以尝试用于AMI后心功能不全的早期判别及AMI后近期死亡危险性的早期评价。Objective：To explore the change of plasma BNP level in patients with acute myocardial infarction（AMI） and its value in forecasting prognosis and recent heart dysfunction.Methods： 100 patients with incipient AMI were enrolled to determine plasma BNP level,left ventricle ejection fraction（LVEF）,myocardial zymogram and troponin I quantitation,and record Killip grading.All the patients were followed up for 4 weeks to observe the relationship between these factors and mortality.Results： 1.In later stage of AMI,BNP had positive correlation with Killip grading.2.In death group,the levels of BNP,Killip grading and CK-MB were all higher than those in survival group（P〈0.01）.Death in recent and later stage of AMI showed positive correlation with levels of BNP,CK-MB and KIllip grading in acute stage.Conclusion： Significant increase of plasma BNP level in AMI high-risk patients in the later stage was related to Killip grading of acute stage,which can be used in early discrimination of AMI cardiac dysfunction and early evaluation of death risk in recent and later stage of AMI.

关 键 词：BNP 急性心肌梗死 心功能 预后 

分 类 号：R542.22[医药卫生—心血管疾病]