高压氧治疗不同程度噪声性听力损失效果的临床研究  

Clinical study of hyperbaric oxygen therapy applied to different level occupational Noise-induced Hearing loss

作　　者：樊春月[1] 郑倩玲[2] 陈建忠[2] 曾飞飞[2] 郭卫军[2] 

机构地区：[1]广东省职业病防治院住院部,广州市510300 [2]广东省职业病防治院医务科,广州市510300

出　　处：《职业与健康》2012年第10期1153-1156,共4页Occupation and Health

基　　金：广东省医学科研基金项目(项目编号:A2009062)

摘　　要：目的观察高压氧治疗不同程度职业噪声性听力损失(ONHL)的效果。方法采用随机对照临床试验的方法,将153例ONHL患者随机分为高压氧治疗组(HBOT组)、高压常氧治疗组(HNC组)和常压常氧治疗组(NNC组)。HBOT组根据听力损失的不同程度分为观察对象组和耳聋组,进行2个疗程(20 d)的治疗,分析高压氧治疗不同程度ONHL的效果。结果治疗后,HBOT组纯音测听(PTA)听阈、自觉耳鸣症状、自觉听力下降症状的改善总有效率均高于NNC组和HNC组(均P<0.01),HBOT组的总体治疗有效率优于NNC组和HNC组(均P<0.01)。HBOT组中,观察对象组PTA听阈、自觉耳鸣症状的改善总有效率分别为50.0%,84.6%,耳聋组的分别为24.2%、84.0%,观察对象组的PTA听阈、自觉耳鸣症状改善总有效率均高于耳聋组(均P<0.05),并且,观察对象组自觉耳鸣症状的改善程度优于耳聋组。耳聋组自觉听力下降的改善总有效率为77.8%。观察对象组和耳聋组的总体治疗有效率比较,差异无统计学意义。结论高压氧治疗不同程度听力损失有一定疗效。[Objective]To investigate the efficacy of hyperbaric oxygen therapy（HBOT） which is applied to different occupational noise-induced hearing loss（ONHL）.[Methods]By adopting the methods of randomized controlled trial,153 patients of ONHL were randomly divided into 3 treatment groups.They were hyperbaric oxygen therapy group（HBOT group）,hyperbaric normoxic control group（HNC group） and normobaric normoxic control group（NNC group）.The HBOT group was divided into objective group and deafness group according the level of hearing loss.The 2-course-treatment lasted 20 days.The effect of hyperbaric oxygen on different degrees of ONHL was analyzed.[Results]After the treatments,the total effective rates of improvement in pure tone audiometry（PTA） threshold,subjective symptoms which included tinnitus and self-hearing loss of HBOT group were higher than those of NNC group and the HNC group（all P0.01）.Significant increase in the total effective rate was noted in the HBOT group compared with the NNC group and the HNC group（all P0.01）.In the HBOT group,the improvement rates of PTA threshold and tinnitus were 50.0% and 84.6% in the objective group,and they were 24.2% and 84.0% in the deafness group respectively.Both of the improvement rates of PTA threshold and tinnitus in the objective group were higher than the deafness group（all P0.05）,and the improvement level of tinnitus in the objective group was significant higher than that of the deafness group.The improvement rate of self-hearing loss in the deafness group was 77.8%.The difference of the total effective rate between the objective group and the deafness group was insignificant.[Conclusion]Hyperbaric oxygen therapy is an effective method for ONHL treatment.

关 键 词：职业性听力损失 高压氧 治疗 

分 类 号：R459.6[医药卫生—治疗学]