无锡市甲型H1N1流感及季节性流感疫苗接种效果分析  

Analysis on immune effect of influenza A(H1N1) and seasonal influenza vaccines in Wuxi

作　　者：石平[1] 钱燕华[1] 何恩奇[1] 缪小兰[1] 邵洁[1] 施超[1] 

机构地区：[1]江苏省无锡市疾病预防控制中心疾控部,214023

出　　处：《职业与健康》2012年第10期1242-1244,共3页Occupation and Health

基　　金：无锡市科技发展计划(项目编号:CSZ01051;CSZ00955);江苏省预防医学科研项目(项目编号:Y201026)

摘　　要：目的调查流感样病例(ILI)和无锡市一般人群中甲型H1N1流感疫苗及季节性流感疫苗的接种情况,评估疫苗接种后对人群的保护效果。方法以无锡市2家哨点医院为基础,采集流感样病例病毒核酸检测阳性的病例作为病例组,共1 529人,同时按照"病例"的电话信息,随机产生电话号码选择、年龄匹配的一般人群作为对照组,共380人。结果病例组甲型H1N1流感疫苗接种率为6.1%(94/1 529),对照组甲型H1N1流感疫苗接种率为12.1%(46/380),两组比较,差异有统计学意义(P<0.01);甲型H1N1流感病例中接种甲型H1N1流感疫苗的比例为12.5%(3/24),门诊检测阴性的ILI病例接种甲型H1N1流感疫苗的比例为6.1%(78/1 273),"接种甲型H1N1流感疫苗"因素的OR值为0.457(P=0.201);以电话调查一般人群(330例)作为对照组,接种甲型H1N1流感疫苗的比例为13.3%(44/330),OR值为1.077(P=0.908)。结论该次调查说明接种甲型H1N1流感疫苗对预防流感样病例有一定效果,但由于样本量较少,24种方法病例对照分析均未得出差异有统计学意义。[ Objective ] To investigate the vaccination rate of influenza A （H1 N1 ） and seasonal influenza vaccines in influenza-like illness （ILI） cases and general population, evaluate the protective effect of vaccines. [ Methods ] 1 529 ILI cases who were positive for influenza virus were collected from 2 sentinel hospitals in Wuxi City, which was the case group. 380 age-matched people （ the control group） were randomly collected according to the cases＂ telephone number. [ Results ] The coverage rate of influenza A （H1N1） vaccine in the case group and the control group was respectively 6. 1% （94/1 529 } and 12. 1% （46/380） , and the difference between two groups was significant （ P 〈0.01 ） The vaccination rate of influenza A （ H1N1 ） vaccine in patients with influenza A （ H1 N1 ） was 12.5% （ 3/24）, and that in ILI cases with negative detection results was 6.1% （78/1 273 ）. OR value of ＂vaccinated with influenza A （ H1 N1 ） vaccine＂was 0.457 （ P = 0.201 ）. The vaccination rate of influenza A （ H1 N1 ） vaccine in the control group （330 people） was 13.3% （44/330）, and OR value was 1. 077（P = 0. 908 ）. [ Conclusion] This investigation shows that influenza A （ H1N1 ） vaccine had certain effect in preventing ILI cases. Because the sample size is small, no significant difference is found by 24 ease-control analysis methods.

关 键 词：甲型H1N1流感 甲型H1N1流感疫苗 接种效果 

分 类 号：R181.8[医药卫生—流行病学]