间接原子吸收法测定药物中盐酸洛美沙星含量  

Determination of lomfloxcin hydrochloridum by indirect atomic absorption spectorscopy

作　　者：李媛[1] 郎惠云[1] 谢志海[1] 

机构地区：[1]西北大学化学系,陕西西安710069

出　　处：《西北大学学报（自然科学版）》2000年第1期39-42,共4页Journal of Northwest University（Natural Science Edition）

摘　　要：首次提出了盐酸洛美沙星的间接原子吸收分析方法。它是基于盐酸洛美沙星在适当的酸度条件下与雷氏盐反应生成不溶性络合物 ,利用测定沉淀剂中铬的量来间接确定盐酸洛美沙星的量。与UV法相比 ,相对偏差小于 1 .3%。线性范围为 80～ 40 0μg· m L-1,回收率为 1 0 1 %～ 1 0 2 %。The method of determining lomefloxcin hydrochloridum indirectly by actomic absorption spectroscopy first is reported. It is based on the reaction of lomefloxcin hydorochloridum with Reinecke′salt in potassium biphthalate hydrochloride buffer solution of pH=3.0,to form quantitatively precipitate of Reinecke′salt lomefloxcin hydrochloridum, determine the amount of Cr 3+ in the precipitate by AAS, and then determine the amount of Cr 3+ in the precipitate by AAS. The relative deviation between this method and UV, is less than 1.3% . The linear range is 80～400μg·mL -1 ,the recovery is 101%～102%.

关 键 词：间接原子吸收光谱法 盐酸洛美沙星 药物分析 

分 类 号：R978.1[医药卫生—药品] O657.31[医药卫生—药学]