^(99m)TcO4^-动静态显像对桥本氏甲状腺炎临床诊断价值  

Clinnical value of 99mTcO4- radionuclide dynamic and static imaging in the diagnosis of Hashimoto＇s thyrioditis

作　　者：张晓辉[1] 彭祖光[1] 李永明[1] 龙贵珍[1] 刘伯儒[1] 

机构地区：[1]肇庆市第一人民医院核医学科,526021

出　　处：《中国实用医药》2012年第12期22-24,共3页China Practical Medicine

摘　　要：目的探讨99mTcO4-甲状腺动静态显像对桥本氏甲状腺炎(慢性淋巴细胞性甲状腺炎,以下简称HT)的诊断价值。方法选取78例临床诊断为HT患者,其中70例经针刺细胞学确诊,8例手术病理确诊,而且2例术后病理明确为HT合并甲状腺乳头状癌;并选取30例健康人为对照组,两组人员均进行甲状腺动静态显像、化学发光法游离甲状腺激素(FT3、FT4),血清超敏TSH(TSH-ul)、甲状腺球蛋白抗体及甲状腺过氧化物酶抗体(TGAb及TPOAb)测定,并根据甲状腺激素水平将HT分为:功能减退组、亚临床甲减组、功能正常组、功能亢进组,分析摄锝率、有无结节、动态血流与甲状腺激素水平及甲状腺相关抗体间的关系,各组与对照组比较,采用统计软件SPSS16.0软件,χ2检验。结果 78例桥本氏甲状腺炎中60例(76.92%)以核素放射性弥漫性高摄取表现,10例(13%)以放射性核素分布大致均匀,摄锝率在正常范围表现,8例(10.26%)以核素放射性分布不均匀,"结节"表现,57例(73.01%)甲状腺相关抗体增高,而对照组30例均为放射性核素分布大致均匀,摄锝率在正常范围表现。结论 HT患者甲状腺摄取功能在不同激素水平间表现出复杂特点,甲状腺动静态显像在桥本氏病诊断与鉴别诊断中具有一定价值。Objective To study the diagnostic value of 99 mTcO4-thyroid dynamic and static imaging using 99 mTcO4-for Hashimoto＇s thyroiditis（chronic lymphoblastic thyroid inflammation,hereinafter referred to as the HT）.Methods 78 cases clinical diagnosis for HT patients was selected,among them 70 cases were diagnosed by needle biopsy,8 cases were confirmed by surgery and pathology,2 cases of postoperative pathologic clear for HT merger thyroid papillary carcinoma,and selection of 30 cases of control group health people.Two groups of researchers were for thyroid dynamic and static imaging,chemicalluminescence method FT3 serum,FT4,persensitivity serum TSH（TSH-ul）,thyroid globulin antibodies and thyroid peroxidase antibodies（TGAb and TPOAb） test,seventy-eight persons with HT were divided into four groups,hypothyroidism stage,subclinical hypothyroidism stage,normal Function stage,hyperthyroidism stage,based on their serum levels of FT3、 FT4 and TSH at the time of visit.Then we analyses the relationship with the uptake rate,nodules,dynamic flow,levels of thyroid hormones and TGAb and TPOAb.Four HT groups compared with the control group,all results obtained were processed by SPSS 16.0 statistical analysis software and compared by the chi-square test.Results 78 cases of Hashimoto＇s thyroiditis in 60 patients（76.92%） with radioactive nuclide diffuse high intake of performance,10 cases（13%） with radioactive nuclide roughly uniform distribution,taken at rates in the normal range performance,uneven distribution of radioactive nuclides（＂nodus＂ performance）,30 cases of control group in were roughly uniform distribution of radioactive nuclides,taken at rates in the normal range performance.Conclusion thyroid images of HT show complex characteristics in different hormone levels,and it has a certain value in diagnosis and differential diagnosis of Hashimoto disease.

关 键 词：桥本氏甲状腺炎 99mTcO4- 甲状腺 放射性核素显像 

分 类 号：R581.4[医药卫生—内分泌]