慢性心力衰竭患者和肽素、尿酸水平变化及其临床意义  

Clinical significance and the expression of copeptin and uric acid in patients with chronic heart failure

作　　者：于红玖[1] 杨明晖[1] 吕田[1] 

机构地区：[1]大连医科大学附属第一医院特需医疗部,辽宁大连116011

出　　处：《大连医科大学学报》2012年第3期244-247,共4页Journal of Dalian Medical University

基　　金：辽宁省临床医学重点专科建设项目(2007)

摘　　要：[目的]探讨慢性心力衰竭(chronic heart failure,CHF)患者血浆和肽素(copeptin)、血清尿酸水平与心功能变化及左室舒张末期内径(LVEDd)之间的关系和临床意义。[方法]选取2010年6月—2010年12月于大连医科大学附属第一医院诊断为慢性心力衰竭患者74例(CHF组)和同期健康体检的健康者39例(正常组),比较两组和肽素、尿酸水平。[结果](1)CHF组血浆和肽素水平及血清尿酸水平明显高于对照组(P<0.01)。血浆和肽素水平在各级心功能组差异无显著性意义。血清尿酸水平随心功能分级逐级升高,差异有显著性意义。心功能Ⅳ级组尿酸水平明显高于Ⅲ级组,Ⅲ级组明显高于Ⅱ级组。(2)和肽素水平及尿酸浓度的升高与LVEDd的大小呈正相关(r=0.43及0.46,P<0.05)。[结论]和肽素和尿酸水平可作为判断CHF患者心功能严重程度、预后的重要指标,两者的联合检测有助于对心功能进行综合评价。[ Objective] To detect the copeptin and uric acid levels in patients with chronic heart failure, and to evaluate the difference of the levels in patients with the different LV diameter （LVEDd）. [ Methods] Seventy- four patients with chronic heart failure as the experimental group, thirty - nine people without organic disease as the control group. The copeptin and uric acid levels were estimated in the experimental group. [ Results] （ 1 ） The levels of plasma eopeptin and serum acid uric in the experimental group were significantly higher than that in control group （ P 〈 0.01 ）. The plasma copeptin levels were not increased with tile severity of cardiac function classification. The serum acid uric levels were signif- icantly increased with the severity of cardiac function classification. （2） The levels of plasma copeptin and serum acid uric were positively correlated with LVEDd （ r = 0.43 and 0.46, P 〈 0.05 ）. [ Conclusion] The higher levels of plasma copep- tin and serum acid uric suggest the wider of LVEDd and the serious standard of CHF.

关 键 词：和肽素 尿酸 慢性心力衰竭 左心室内径 

分 类 号：R541.6[医药卫生—心血管疾病]