应力性骨折武警新兵患者血清CGRP及SP水平变化及其临床意义  

Serum levels of CGRP and SP in armed police recruits with stress fracture and its clinical significance

作　　者：陆斌[1] 李广琪[1] 李建武[1] 

机构地区：[1]中国人民武装警察部队陕西省总队医院,西安710054

出　　处：《中国矫形外科杂志》2012年第12期1117-1119,共3页Orthopedic Journal of China

基　　金：卫生行业科研专项项目(编号:201002018)

摘　　要：[目的]探讨应力性骨折(stress fracture,SF)新兵患者血清中降钙素基因相关肽(calcitonin gene-re-lated peptide,CGRP)及P物质(substance P,SP)水平及其临床意义。[方法]采用1:1配比的病例对照研究,选取武警新兵应力性骨折病例及正常对照各40例,采用ELISA法检测血清中CGRP及SP水平。[结果]应力性骨折新兵患者在入院时、入院后24h及72h血清中CGRP及SP水平明显升高,与正常对照组相比有统计学差异(P<0.01)。[结论]应力性骨折患者体内CGRP及SP水平升高,CGRP与SP可能参与了应力性骨折的发病过程。[ Objective] To explore the serum levels of caleitonin gene-related peptide （CGRP） and substance P （SP） in armed police recruits with stress fracture （SF） and its clinical significance. [ Method] Forty recruits with SF and forty one by one matched controls were involved in this study. The serum levels of CGRP and SP were measured by ELISA. [ Result] The se- rum levels of CGRP and SP were significantly increased in admission, 24 h and 72 h after admission in the recruits with SF. There were significant difference between the recruits with SF and the controls （P 〈0.01 ）. [ Conclusion] The serum levels of CGRP and SP increased in the recruits with SF. CGRP and SP may be involved in the pathogenesis of SF.

关 键 词：应力性骨折 CGRP SP 

分 类 号：R82[医药卫生—临床医学]