子宫内膜异位症在位内膜MUC1与TNFR-I表达的关系  

Relationship between the expressions of MUC1 and TNFR-I in endometriosis endometrium

作　　者：沈芳荣[1] 陈友国[1] 刘明[1] 冯亚红[1] 

机构地区：[1]上海交通大学医学院苏州九龙医院妇产科,江苏省215021

出　　处：《江苏医药》2012年第10期1161-1164,共4页Jiangsu Medical Journal

基　　金：苏州市科技支撑项目(sys201064)

摘　　要：目的检测子宫内膜异位症(EMs)患者在位内膜黏蛋白1(MUC1)和肿瘤坏死因子受体I(TNFR-I)的表达,探讨血清中肿瘤坏死因子(TNF-α)含量的调控机制及与EMs性不孕的内在联系。方法采集28例EMs患者(EMs组)及26例输卵管因素不孕患者(对照组)的在位子宫内膜,采用IHC方法检测内膜MUC1的表达,Western blot法检测TNFR-I的表达;用ELISA法检测血清TNF-α水平。结果 EMs在位内膜MUC1在不同月经周期的表达差异不明显,其在分泌中期的表达量较对照组明显减少。EMs组血清TNF-α含量显著高于对照组;而TNFR-I表达则低于对照组。结论 EMs在位内膜MUC1表达的改变,可能是EMs性不孕的原因之一;TNF-α缺乏促进在位内膜MUC1表达的作用可能与TNFR-I的低表达有关。Objective To detect the expressions of mucin-1 and tumor necrosis factor receptor-I （TNFR-I） in endometriosis （EMs） endometrium, and investigate the relationship between the regulation of serum TNF-α and EMs-related infertility. Methods The endometrium was taken in 28 EMs patients （group EMs） and 26 patients with oviduct block（group C） during operation. The expressions of MUC1 and TNFR-I in endometrium were detected with IHC and Western blot methods, respectively. Serum TNF-α was determined by ELISA. Results The mucin-1 expression was not significantly different among different menstrual cycles in group EMs, but was higher in middle luteal phase in group EMs than that in group C. Serum TNF-α was higher, but TNFR-I expression was lower in group EMs than those in group C. Conclusion The change of mucin-1 expression in endometrium might be one of the factors for EMs-related infertility. That TNF-α lacks to promote mucin-1 expression in endometrium may be related to decreased TNFR-I expression.

关 键 词：子宫内膜异位症 黏蛋白1 肿瘤坏死因子受体I 

分 类 号：R713[医药卫生—妇产科学]