老年高血压患者高尿酸血症与缺血性脑卒中相关性分析  

Analysis of relationship between hyperuricemia and ischemic stroke in elderly patients with hypertension

作　　者：王娓娓[1] 张红苗[1] 张莹[1] 李洁茹[1] 

机构地区：[1]云南昆明医学院第二附属医院干疗心内科,060031

出　　处：《中华老年医学杂志》2012年第6期462-464,共3页Chinese Journal of Geriatrics

基　　金：云南省教育厅科研基金（2010Y180）

摘　　要：目的探讨老年高血压患者高尿酸血症与缺血性脑卒中发生的相关性。方法分析100例60岁以上老年原发性高血压患者，根据尿酸水平分为对照组（尿酸≤417μmol／L，51例）和实验组（尿酸≥417μmol／L，49例），比较两组血尿酸水平与缺血性脑卒中之间的关系。结果两组在年龄、体质指数（BMI）、饮酒史、糖尿病史等一般情况方面差异无统计学意义（P〉0．05）。入院时的尿酸水平，吸烟史及脑卒中发生率差异有统计学意义（P〈0．05）。实验组不同时间段各组问尿酸和脑卒中严重程度评分均有统计学意义（P〈0．05）。Logistic回归分析发现，调整脑卒中的其他危险因素后，实验组的脑卒中的发生率是对照组的2．88倍（β=1．059，OR=2．884，P=0．03）。结论尿酸水平增高与老年原发性高血压患者脑卒中发生密切相关。Objective To investigate the relationship between blood uric acid and ischemie stroke in the elderly with hypertension. Methods Totally 100 elderly patients with hypertension were divided into study group （blood uric acid≥417 μmol/L, n= 49） and control group （blood uric acid〈417 μmol/L, n= 51）. The relationship between the level of uric acid and ischemic stroke were analyzed in two groups. Results There were not significant differences in age, body mass index （BMI）, smoking and drinking, diabetes（P〉0.05） between the groups, but there were differences in uric acid levels, smoking history, and stroke incidence at admission into hospital（P〈0.05）. In study group, uric acid and stroke severity score were significantly related in different times（P〈0.05）. After adjusting the related risk factors, logistic multiple regression analysis showed that the odd ratio of ischemic stroke was greater in study group than in control group （β=1. 059,OR=2. 884, P=0.03）. Conclusions Increased levels of uric acid are closely related with stroke in elderly patients with hypertension.

关 键 词：高血压 尿酸 缺血性卒中 

分 类 号：R544.1[医药卫生—心血管疾病] R743.3[医药卫生—内科学]