氨氯地平阿伐他汀钙对老年高血压并存高脂血症患者动脉粥样硬化水平的影响  

Influence of Amiodipine besylate/atorvastatin calcium on atherosclerosis level in elderly with hypertension and hyperlipemias

作　　者：陈安[1] 王东之[1] 徐更华[1] 王俊[1] 陶晓剑[1] 王益波[1] 杨晓翠[1] 宋洁[1] 

机构地区：[1]浙江省上虞市中医院心血管内科,312300

出　　处：《中华老年医学杂志》2012年第6期469-471,共3页Chinese Journal of Geriatrics

基　　金：浙江省上虞市科技计划项目（2010041）

摘　　要：目的探讨氨氯地平阿托伐他汀钙（多达一）对老年人高血压并存高脂血症患者动脉粥样硬化水平的影响。方法选取我院收治的108例高血压并存高脂血症患者，并将其随机均分为对照组及观察组，每组54例。其中对照组采用利尿剂、血管紧张素转换酶抑制剂、钙拮抗剂及B受体阻滞剂等常规降压方法治疗；观察组在其基础上加用多达一，两组同时服用，6个月为1疗程。对比观察两组治疗后血脂水平及颈动脉超声检测结果。结果观察组治疗后较对照组总胆固醇（TC）[（4．23±0．79）mmol／L比（5．32±1．23）mmol／L]、三酰甘油（TG）[（1．53±0．35）mmol／L比（5．32±1．23）mmol／L3、低密度脂蛋白胆固醇（LDL—C）[（3．19±0．59）mmol／L比（4．07±O．79）mmol／L]水平明显下降，高密度脂蛋白胆固醇（HDL—c）[（1．53±0．95）mmol／L比（1．32±0．83）mmol／L]明显升高，差异有统计学意义（P〈0．05）。观察组治疗后颈动脉超声检查冠状动脉钙化积分（LN）[（1．61±0．76）分比（2．24±0．89）分]和颈动脉内膜中层（IMT）[（0．76±0．22）mm比（0．98±0．28）mm]水平较对照组治疗后明显下降（P〈O．05）。结论多达一能够有效降低血脂，缓解动脉粥样硬化，适用于高血压合并高脂血症患者。Objective To investigate influence of amlodipine /atorvastatin on atherosclerosis in the elderly with hypertension and hyperlipidemia. Methods Totally 108 cases with hypertension and hyperlipidemia in our hospital were randomly divided into control group and observation group （n 54 each）. The control group received conventional antihypertensive treatment such as diuretics, angiotensin-converting enzyme inhibitors, calcium antagonists; the observation group received amlodipine and atorvastatin combination tablet as add-on therapy to the above drugs for 6 months. The blood lipid level and carotid artery ultrasound detection results were observed and compared between the two groups after treatment. Results The levels of TC [（4.23 ±0.79）mmol/L vs. （ 5.32 ± 1.23）mmol/L], TG[（1.53 ± 0.35） mmol/L vs. （5.32 ±1.23） mmol/L], LDL-C [（3.19 ± 0.59） mmol/L vs. （4. 074-0.79）mmol/L^were decreased, while HDL-C[（1.53±0.95）mmol/L vs. （1.32±0.83）mmol/L]were increased in observation group after treatment as compared to control group （all P〈0.05）. After carotid arteryultrasonography, the LN[（1.61~0.76）scores vs. （2.24±0.89）scores and IMT [（0.76 ± 0.22）mm vs. （0.98 ± 0.28）mm] levels were lower in observation group after treatment than in control group （P〈0.05）. Conclusions Amlodipine/atorvastatin combination can reduce blood lipids and alleviate atherosclerosis. It is suitable for elderly patients with hypertension and hyperlipidemia.

关 键 词：高血压 高脂血症 动脉粥样硬化 

分 类 号：R544.1[医药卫生—心血管疾病]