肝衰竭患者并发全身炎症反应综合征的诱因及预后分析  

Analysis of inducement and prognosis in liver failure patients with systemic inflammatory response syndrome

作　　者：胡凤霞[1] 黄小平[1] 甘建和[1] 江敏华[1] 罗二平[1] 黄燕[1] 吕胜祥[1] 顾静[1] 杨柳[1] 

机构地区：[1]苏州大学附属第一医院感染病科,江苏省215006

出　　处：《江苏医药》2012年第11期1304-1306,共3页Jiangsu Medical Journal

基　　金：国家"十二五"科技重大专项子课题(2012ZX10002-004)

摘　　要：目的分析慢加急性肝衰竭(ACLF)患者发生全身炎症反应综合征(SIRS)的常见诱因,探讨SIRS与ACLF临床转归的关系。方法回顾性分析493例ACLF患者的临床资料。按是否合并SIRS分为SIRS组(282例)和非SIRS组(211例),分析SIRS的发病诱因及临床转归;应用Logistic回归分析观察不同诱因对预后的影响。结果 ACLF患者SIRS发生率57.20%。引起SIRS最常见诱因为感染和消化道出血,且与预后明显相关(OR分别为4.355和3.557,P<0.05)。SIRS严重者,病死率高(P<0.05)。结论感染与消化道出血是ACLF发生SIRS的最常见诱因,且是影响预后的独立危险因素。Objective To analyze the inducement and prognosis in acute-on-chronic liver failure （ACLF） patients with systemic inflammatory response syndrome （SIRS）. Methods Data of 493 patients with ACLF were analyzed retrospectively. The patients were assiged into two groups of A （282 cases, with SIRS） and B（211 cases, without SIRS）. The relationship between the inducements for developing＇SIRS and the prognosis was analyzed by logistic regression analysis. Results The incidence of SIRS in ACLF patients was 57.20~/~. The most common inducements of SIRS were infection and gastrointestinal bleeding, which were closely correlated to the prognosis （OR = 4. 355 and 3. 557, P^0. 05）. The more severe SIRS, the higher mortality. Conclusion Infection and gastrointestinal bleeding are the common inducements in ACLF patients with SIRS,which are the independent factors to affect the prognosis.

关 键 词：肝衰竭 全身炎症反应综合征 

分 类 号：R517[医药卫生—内科学]