多能的SoxB1家族基因  

The Pluripotent SoxB1 Family Genes

作　　者：胡胜男[1] 李逸平[1] 

机构地区：[1]中国科学院上海生命科学研究院生物化学与细胞生物学研究所国家细胞生物学重点实验室,上海市分子男科学重点实验室,上海200031

出　　处：《中国细胞生物学学报》2012年第6期611-616,共6页Chinese Journal of Cell Biology

基　　金：国家重点基础研究发展规划(973计划)(No.2011CB966301)资助项目~~

摘　　要：SoxB1基因家族编码一类含有HMG DNA结合结构域的转录因子。目前,已经鉴定出的SoxB1家族成员包括脊椎动物中共有的Sox1a/b、Sox2、Sox3以及硬骨鱼类中特有的Sox19a/19b,它们在性别决定、神经元特化、"干"性细胞自我更新及全能性维持、胚层发育等过程中发挥重要作用。向小鼠成纤维细胞中导入四个关键因子Sox2、Oct4、c-Myc及Klf4,可以成功地将体细胞诱导成具有分化全能性的干细胞,证明了SoxB1因子在发育过程中不可或缺的重要性,也极大地推动了关于SoxB1家族基因的研究。该文将围绕SoxB1基因的最新研究进展作一综述。SoxB1 genes are group of transcriptional factors containing the HMG DNA binding domain. Till now the identified soxB1 family members include the Sox1, Sox2 and Sox3 in all vertebrate and Sox19a/Sox19b existing exclusively in teleost, which are involved in sexual determination, stem cell self-renewal/pluripotency maintenance and germ layer development. Forced expression of four transcriptional factors, Sox2, Oct4, c-Myc and Klf4 could successfully induce pluripotency stem cells from the somatic cell, which demonstrated the SoxBl factors play an important role during the developmental process and greatly promoted its related basic research. In this review, we mainly focused on the current advance on SoxB1＇s function.

关 键 词：SoxB1 性别决定 神经元特化 干细胞全能性 胚层发育 

分 类 号：Q75[生物学—分子生物学]