芝麻素对自发性高血压大鼠肾病的保护作用  

Renal protective effect of sesamin in spontaneously hypertensive rats

作　　者：杜少陵[1] 杨解人[1] 张俊秀[1] 李文星[1] 

机构地区：[1]皖南医学院国家中医药管理局中药药理三级实验室,安徽芜湖241002

出　　处：《中国临床药理学与治疗学》2012年第5期502-507,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：安徽省教育厅自然科学研究基金重点项目(No2006KJ099A);芜湖市2008年度科技计划重点项目(No2008512)

摘　　要：目的:观察芝麻素对自发性高血压大鼠(SHR)肾病的保护作用。方法:SHR灌胃芝麻素(160、80、40mg/kg)16周,每日一次。测定动物给药前后血压及给药后血Cr和BUN含量;HE染色观察肾小球病理变化;MASSON染色观察肾小球和肾间质胶原纤维变化;透射电镜观察肾小球超微结构。结果:芝麻素(160mg/kg)给药16周,能明显降低大鼠的血压、血Cr和BUN含量;改善肾小球变形、萎缩、硬化甚至玻璃样变等病理改变;肾小球系膜区未见明显扩大,基底膜未增厚,足突细胞无明显融合;肾小管细胞损伤和间质纤维化明显减轻。结论:芝麻素具有改善肾功能、保护肾脏作用。To evaluate the protective effect of sesamin on kidney damage in spontane- ously hypertensive rats （SHR）. METHODS： Sesamin （ 160,80,40 mg/kg） was administrated to SHR intragastrically once a day for 16 weeks. The blood pressure （BP） before and after admin- istration were measured. After the last BP measuring, rats were anesthetized. 5 mL ofblood sample were collected from abdominal aor- ta for the detecting of blood urea nitrogen （BUN） and creatinine（Cr） concentration. The kidney was excised for HE and MASSON stai- ning to observe the changes of pathology and collagen fibers. Glomerular ultrastructure was observed by transmission electron microscopy. RESULTS： After the administration of sesaminfor 16 weeks, the BP,Cr and BUN were lowered significantly. Pathological changes such as glo- merular distortion, atrophy, sclerosis and hya- linization were improved. There was no signifi- cant expansion in mesangial area, no thickening in basement membrane and no significant cell fu- sion of podocytes. Renal tubular cell injury and interstitial fibrosis was significantly reduced. CONCLUSION： Sesamin can improve the renal function of SHR kidneys and protect kidneys from damage.

关 键 词：芝麻素 自发性高血压大鼠 肾脏 病理学变化 超微结构 间质纤维化 

分 类 号：R965.2[医药卫生—药理学]