高效抗逆转录病毒疗法引起线粒体毒性的研究进展  

Research progress in nfitochondrial toxidty of highly active anth-etrovirai therapy

作　　者：黄宝国[1] 蔡卫平[1] 唐小平[1] 

机构地区：[1]广州医学院附属市八人民医院研究所,510060

出　　处：《国际流行病学传染病学杂志》2012年第3期182-185,共4页International Journal of Epidemiology and Infectious Disease

摘　　要：HAART是目前治疗HIV感染者／艾滋病患者最有效的治疗方法。近年的研究表明，HAART显著降低了艾滋病相关疾病的发病率和死亡率。然而，随着HAART使用的增加，其毒副作用问题日益彰显，其中线粒体毒性成为研究热点。由于国内对HAAT线粒体毒性研究较少，目前我国尚无监测相关线粒体毒性的有效方法。此文对HAART导致线粒体毒性的临床表现、发病机制及实验室检测等进行了综述。Highly active antiretroviral therapy（HAART） is the most effective method for HIV/AIDS treatment. It dramatically decreases the morbidity and mortality. But along with its wide use, serious side effects are more often seen. Among them, mitochondrial toxicity is one of the greatest concerns. Due to the lack of research in mitochondrial toxicity in China, no effective monitor for mitochondrial damage has been used. In this article, the clinical manifestation, mecha- nism and monitoring methods of mitochondrial toxicity are reviewed.

关 键 词：抗逆转录病毒治疗 高效 线粒体 毒性 艾滋病 

分 类 号：R51[医药卫生—内科学]