不同中心频率下双极电脉冲的生物医学效应分析  

An Analysis on Biomedical Effects of Bipolar Electric Pulses at Different Central Frequency

作　　者：谈亚芳[1] 杨宏春[1] 徐军[1] 张怡[2] 吴明和[1] 邹姮[2] 

机构地区：[1]电子科技大学物理电子学院,成都610054 [2]四川大学华西妇女儿童医院生物医学超声/妇科肿瘤实验室,成都610041

出　　处：《生物医学工程学杂志》2012年第3期438-442,共5页Journal of Biomedical Engineering

摘　　要：采用多层球对称细胞模型,针对恶性Tonsillar B细胞和Jurkat T淋巴细胞,利用电路分析方法,计算了不同中心频率的一阶高斯脉冲在细胞各部分的电压分布;给出了中心频率与细胞膜跨膜电压间的定量关系和细胞核膜电穿孔的最佳频率;研究了细胞膜电穿孔和纳秒脉冲致DNA降解的原因。本文工作为双极瞬态脉冲应用于恶性肿瘤治疗提供了参考。Adopting the cell model of multilayer spherical symmetry and the circuit analysis, the present paper gives the calculated results of the voltages on each of several parts of malignant Tonsillar B-eells and Jurkat T lymphoeytes when the first-order Gaussian pulses at different central frequency apposed on them. The relationship between the central frequency and the transmembrane voltages of plasma membrane is also given. The optimum frequency causing electroporation in nuclear envelope is given as well. The paper discusses the reasons of electroporation in membrane and DNA degradation in nuclear. The work provides a reference for usage of transient bipolar electric pulses in cancer treatment.

关 键 词：电穿孔效应 跨膜电压 阈值条件 细胞凋亡 

分 类 号：R318.0[医药卫生—生物医学工程]