基于经血管介入的预测自动推药动物实验研究  

Experimental Study on Animal with Automatic Drug Injection Based on Predictive Control for Vascular Interventional Therapy

作　　者：涂海燕[1] 袁支润[1] 谢晓东[2] 王朝华[2] 张昌伟[2] 程美雄[2] 范锋[2] 张紫寅[2] 张红良[3] 

机构地区：[1]四川大学建筑与环境学院,成都610065 [2]四川大学华西医院神经外科,成都610041 [3]四川大学分析测试中心,成都610064

出　　处：《生物医学工程学杂志》2012年第3期460-464,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(10672110)

摘　　要：本文着重讨论了经血管介入的预测自动推药动物实验,研究了动物实验中存在的参数时变性与个体差异性,改进、完善了体外脉动流模拟实验中的模型和算法,增强了模型的时变适应性及容错性。实验结果表明,在心舒张期推药较之收缩期推药,靶目标血药浓度更高;经改进的与心动周期同步的预测控制推药方法,可进入临床试验。This paper focuses on the animal experiment of automatic drug delivery based on predictive control for vas- cular interventional therapy. Improvement of drug delivery system based on predictive control used in simulated ex- periments was put forward after the presence of time varying parameters and the characteristics of individual differ- enees of animal had been studied. The adaptability of time varying parameters and fault tolerance of the system were also enhanced. Dif{erent injection methods were tested on animals. It is proved that higher target blood concentration can be reached while injecting during diastolic than that while injecting during systolic or injecting at a constant speed within the whole cardiac cycle. The results also showed that the improved drug injection system based on predictive control which synchronizes with the cardiac cycle could be applied to clinical trials.

关 键 词：介入血管推药 预测自适应控制 动物实验 血流动力学 模拟实验 

分 类 号：R96[医药卫生—药理学]