α-磷酸三钙／HA晶须／羧甲基壳聚糖-明胶复合增强多孔骨水泥的制备研究  

Preparation of α-Tricalcium Phosphate/HA Whisker/Carboxymethyl Chitosan-Gelatin Composite Porous Bone Cement

作　　者：卫冬娟[1] 张翔[1] 顾建文[2] 胡萍[1] 杨为中[1] 陈东宁[3] 周大利[1] 

机构地区：[1]四川大学材料科学与工程学院,成都610065 [2]成都军区总医院,成都610068 [3]四川大学吴玉章学院,成都610065

出　　处：《生物医学工程学杂志》2012年第3期491-495,共5页Journal of Biomedical Engineering

摘　　要：为研究羟基磷灰石(HA)晶须和羧甲基壳聚糖-明胶(CMC-Gel)对多孔磷酸钙骨水泥(CPC)力学性能的影响,将α-磷酸三钙(α-TCP)粉、HA晶须和致孔剂L-谷氨酸钠按一定的质量比进行混合,加入调和液制备成α-TCP/HA晶须复合多孔骨水泥,然后将其浸润到一系列不同CMC和Gel质量比的溶液中以制备α-TCP/HA晶须/CMC-Gel复合增强多孔骨水泥,对其进行抗压强度测试和扫描电镜观察。结果显示,当HA晶须含量为4%,未添加CMC和Gel时,α-TCP/HA晶须复合多孔骨水泥的抗压强度达到2.57MPa,与未复合HA晶须的骨水泥相比提高了81%;当CMC和Gel的质量比为50∶50时,α-TCP/HA晶须/CMC-Gel复合多孔骨水泥的抗压强度达到最大值3.34MPa,与单纯的多孔α-TCP骨水泥相比提高了135%,同时韧性也有较大改善。In order to investigate the effects of HA whisker and carboxymethyl chitosan-gelatin（CMC-Gel） on the mechanical properties of porous calcium phosphate cement, a series of α-tricalcium phosphate （α-TCP）, HA whisker and L-sodium glutamate porogen with different mass fractions were mixed, and setting liquid was added to them to prepare α-TCP/HA whisker composite porous bone cement. Then, the cement was immersed in a series of CMC-Gel solutions which had different weight ratios of CMC to Gel to prepare α-TCP/HA whisker/CMC-Gel composite porous bone cement. The compressive strengths and microstructure of cement were characterized by mechanical testing machine and SEM. The results showed that when the mass fraction of HA whisker is 40/＇60, the compressive strength of α-TCP/HA whisker composite porous bone cement reaches 2.57MPa, which is 1.81 times that of a-TCP bone cement. When the weight ratio of CMC to Gel is 50 ： 50, the compressive strength of α-TCP/HA whisker/CMC-Gel composite porous bone cement is 3.34MPa, which is 2.35 times that of a-TCP bone cement, and the toughness of the composite cement is greatly improved as well.

关 键 词：磷酸钙骨水泥 HA晶须 羧甲基壳聚糖-明胶 增强 

分 类 号：R318.08[医药卫生—生物医学工程]