采用不同汉语言语刺激声测试听觉事件相关电位的对比研究  

Comparative study of auditory event-related potentials evoked by different Chinese speech stimuli

作　　者：周文芳[1] 梁勇[1] 

机构地区：[1]南方医科大学附属南方医院耳鼻咽喉头颈外科,广州510515

出　　处：《临床耳鼻咽喉头颈外科杂志》2012年第12期542-546,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：广东省科技计划项目(No:2010B031600099)

摘　　要：目的:比较不同刺激声(包括纯音、实意字、双音节词和数字)诱发的听觉事件相关电位(auditory e-vent-related potentials,AERP)反应特性,探讨汉语言语声刺激测试中国人AERP的可行性,进一步探讨AERP的产生机制和临床意义。方法:采用纯音和3种不同的汉语言语作为声刺激对37例(70耳)正常青年人进行AERP测试,对波形进行量化评分,比较各种刺激声诱发的AERP潜伏期、幅值及波形评分。结果:汉语言语和纯音均可以记录到典型的AERP波形,其中以刺激声为双音节词最容易记录到,各种刺激声对P3的引出率差异有统计学意义(χ2=0.046,P<0.05)。56耳在各种言语及纯音刺激时均能记录到AERP的波形表明,P3波形量化评分及N2-P3振幅在不同刺激声之间的差异均无统计学意义(均P>0.05),但字和双音节词诱发的AERP波形较数字和纯音平滑,杂波少。数字诱发的P3潜伏期较其他组长,且差异有统计学意义(均P<0.05),而其他组间的P3潜伏期相比较则差异均无统计学意义(均P>0.05)。结论:除纯音和字外,汉语言语的其他形式,如双音节词、数字也符合AERP测试刺激声的要求,可以得到满意的AERP波形,同样适用于中国国民的AERP测试,为言语测试AERP在临床上的进一步推广提供了一种更适合中国国民的测试方法。Objective： To research the responsibility and mechanism of auditory event-related potentials （AERP） evoked by pure-tone and different Chinese speech（including single-syllable words, two syllable words and munbers） stimuli respectively. Meanwhile, to explore feasibility of using different Chinese speech forms as stimu lation to evoke AERP in Chinese people. Method： AERPs were measured in 37 young normal post-graduated students（70 ears） with pure-tone and three different Chinese speech forms as stimuli. The mean incidence rates, latencies and amplitudes of AERPs were analyzed, the waveforms of AERPs were quantitatively scored. Then all data were statistically analyzed and compared. Result.. The typical wave P1, N1, P2, N2 and P3 of AERPs could be recorded by both pure-tone and three different Chinese speech stimuli, in which the Chinese two-syllable word was most likely to evoked AERP than pure-tone and remains of Chinese speech forms, and the differences were statisti- cal signifieanee（χ^2 =0. 046 ,P〈0.05）. The quantitative scores and amplitudes of P3 evoked by puretone and three different Chinese speech stimuli were analyzed in 56 ears, whose results showed no significant difference（P〉 0.05） among different stimuli. However, the waveforms of AERPs were smoother and much satisfied evoked by Chinese character and two-syllable word than pure-tone and Chinese number stimuli. The latencies of P3 evoked by number stimulus were significant longer than by other stimuli（P〈0.05）. Nevertheless, the latencies of P3 were no significant differences among the other stimuli（P〉0.05）. Conclusion： Besides puretone and Chinese single-syllable words, other Chinese speech such as two-syllable words and numbers could be used to evoke AERP with satisfied waveform, which indicated that the Chinese character, two-syllable words and numbers were available to apply for AERP measurement as stimuli for Chinese people.

关 键 词：听觉事件诱发电位 汉语 言语 纯音 年青人 

分 类 号：R764[医药卫生—耳鼻咽喉科]