阻塞性睡眠呼吸暂停综合征动物模型的建立方法  

An animal model of obstructive sleep apnea syndrome

作　　者：杨蕾[1] 胡滢洁[1] 张孝文[1] 

机构地区：[1]广州医学院第一附属医院耳鼻咽喉头颈外科,广州510120

出　　处：《临床耳鼻咽喉头颈外科杂志》2012年第12期569-572,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：阻塞性睡眠呼吸暂停综合征(OSAS)因其高发病率和对人体多个系统的严重危害,已成为近年来多学科研究的热点。英格兰牛头犬(Englishbulldog)〔1〕、中国广西陆川猪〔2〕及最近发现的新西兰肥胖的(New Zealand obese)小鼠〔3〕这些自发性OSAS动物模型由于来源相对困难。Obstructive sleep apnea syndrome（OSAS） is endangering human health seriously now. We had re- viewed some typical animal model which had at least one OSAS character of intermittent hypoxia and/or hypercap- nia, upper airway obstruction and sleep structure disorder. However, all of these models could not simulate clini- cal and pathological features of OSAS completely. Establishing a suitable animal model to study OSAS and related diseases is very important.

关 键 词：阻塞性睡眠呼吸暂停综合征 低氧血症 高碳酸血症 上气道阻塞 睡眠紊乱 动物模型 

分 类 号：R563.8[医药卫生—呼吸系统]