人乳头瘤病毒31型诱发宫颈癌形成的研究进展  

Advance in research on cervical cancer induced by human papillomavirus 31

作　　者：张凝[1] 井申荣[1] 

机构地区：[1]昆明理工大学生命科学与技术学院,昆明650000

出　　处：《中国生物制品学杂志》2012年第6期789-792,共4页Chinese Journal of Biologicals

基　　金：国家"863"计划重大项目资助(2006AA02A227)

摘　　要：宫颈癌是导致妇女死亡的第2大癌症。人乳头瘤病毒(Human Papillomavirus,HPV)感染是导致宫颈癌发生的主要原因。HPV是一种具有严格种属特异性、无包膜、双链闭环小型DNA病毒,根据其致病力的强弱,可分为高危型和低危型。在我国,除HPV16、18为常见类型外,HPV31型也是一种发病率较高的类型。本文对HPV31流行病学概况、感染细胞及增值过程、主要蛋白作用机制及其他致癌因素等方面作一综述。Cervical cancer causes the highest mortality in women in addition to breast cancer.As the main pathogen of cervical cancer,human papillomavirus（HPV） is a kind of strict species-specific,non-enveloped,small closed circular double-stranded DNA virus,which is divided into high-risk and low-risk types according to its virulence.In China,in addition to HPV16 and 18,HPV31 also induces a high incidence of cervical cancer.This paper reviews the epidemiology,course of infection of host cells and proliferation of HPV31,the carcinogenic mechanism of HPV major proteins as well as other factors which induce the development of cervical cancer.

关 键 词：宫颈癌 人乳头瘤病毒31 感染 

分 类 号：R373.9[医药卫生—病原生物学] R737.33[医药卫生—基础医学]