抗纤软肝冲剂抗大鼠肝纤维化的实验研究  

Experimental Studies of the Kangxian Ruangan Granule on Anti hepatic Fibrosis in Rats

作　　者：熊益群[1] 严红梅[2] 张赤志[1] 

机构地区：[1]湖北中医学院肝病研究所,武汉430061 [2]湖北中医学院,96级研究生武汉430061

出　　处：《中国实验方剂学杂志》2000年第2期28-30,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：湖北省教委重点资助!(96A02)

摘　　要：采用四氯化碳（ＣＣｌ４）高脂低蛋白等复合因素诱导的大鼠肝纤维化模型，以秋水仙碱作对照，观察抗纤软肝冲剂对肝功能、免疫学、肝纤维化相关指标、肝组织羟脯氨酸（Ｈｙｐ）及肝组织病理学的影响。结果：抗纤软肝冲剂和秋水仙碱有良好的抗肝纤维化效果，其中抗纤软肝冲剂有显著改善肝功能、调节免疫功能、降低免疫复合物（ＩＣ）、降低肝纤维化相关指标和Ｈｙｐ 含量的作用。The effect and mechanism of the Kangxian Rungan granule (KXRG) on antihepatic fibrosis were studied in rat model of hepatic fibrosis induced by complex factors of CCl\-4 and foods of high fat and low protein.The results showed that KXRG and colchicine had good effects on anti\|hepatic fibrosis.KXRG could obviously improve liver functions,regulate immunologic functions and decrease immunologic compound(IC),relevant index on hepatic fibrosis and the level of hydroxyproline(Hyp).

关 键 词：肝纤维化 中医药疗法 动物实验 抗纤软肝冲剂 

分 类 号：R286.55[医药卫生—中药学] R285.5[医药卫生—中医学]