Development and Characterization of an Electrochemical Sensor for Cinchonidine Detection Based on Molecularly Imprinted Polymer with Modified Rosin as Cross-linker  

作　　者：LIU Li TAN Xue-cai ZHAO Dan-dan WANG Lin LEI Fu-hou HUANG Zai-yin 

机构地区：[1]School of Chemistry and Ecological Engineering,Guangxi University for Nationalities,Nanning 530008,P.R.China [2]Guangxi Key Laboratory of Chemistry and Engineering of Forest Produts,Guangxi University for Nationalities,Nanning 530008,P.R.China [3]Key Laboratory of Chemical and Biological Transforming Process,Guangxi University,Nanning 530008,P.R.China

出　　处：《Chemical Research in Chinese Universities》2012年第3期410-414,共5页高等学校化学研究（英文版）

基　　金：Supported by the National Nature Science Foundation of China(Nos.21065001 and 30960306);the Natural Science Foundation of Guangxi Province,China(Nos.0639025,0991084 and 0991001z);the Fund of Guangxi Key Laboratory of Chemistry and Engineering of Forest Products,China(No.GXFC08-06);the Project of Education Department of Guangxi Province,China(No.200812MS074);the Innovation Project of Guangxi University for Nationalities,China(No.gxun-chx2011086)

摘　　要：Molecularly imprinted polymers（MIPs） were applied as molecular recognition elements to an electro- chemical sensor for cinchonidine（CD）. A kind of MIP was synthesized with cinchonidine as template, modified ro- sin（ethylene glycol maleic rosinate acrylate） containing the skeleton of phenanthrene rings as cross-linker and me- thylacrylic acid as functional monomer. MIP membrane was prepared on a glassy carbon electrode for the determina- tion of CD via free radical polymerization method. Electrochemical impedance spectroscopy（EIS） and cyclic vol- tammetry（CV） were used to characterize the membrane electrochemical behavior in electrode fabrication process. The experimental conditions were discussed. Under optimum conditions, it was found that the response of peak cur- rents was linear to the concentration of CD in a range of 0.013-2.26 mmol/L. The detection limit for CD is 1 μmol/L the relative standard deviation for 100 μmol/L CD is 1.34% and the incubation time is 2 min. The sensor was applied to the determination of CD in urine samples with satisfactory results.Molecularly imprinted polymers（MIPs） were applied as molecular recognition elements to an electro- chemical sensor for cinchonidine（CD）. A kind of MIP was synthesized with cinchonidine as template, modified ro- sin（ethylene glycol maleic rosinate acrylate） containing the skeleton of phenanthrene rings as cross-linker and me- thylacrylic acid as functional monomer. MIP membrane was prepared on a glassy carbon electrode for the determina- tion of CD via free radical polymerization method. Electrochemical impedance spectroscopy（EIS） and cyclic vol- tammetry（CV） were used to characterize the membrane electrochemical behavior in electrode fabrication process. The experimental conditions were discussed. Under optimum conditions, it was found that the response of peak cur- rents was linear to the concentration of CD in a range of 0.013-2.26 mmol/L. The detection limit for CD is 1 μmol/L the relative standard deviation for 100 μmol/L CD is 1.34% and the incubation time is 2 min. The sensor was applied to the determination of CD in urine samples with satisfactory results.

关 键 词：Ethylene glycol maleic rosinate acrylate CINCHONIDINE Molecularly imprinted polymer Electrochemicalsensor 

分 类 号：O641.3[理学—物理化学] TP212.2[理学—化学]