肺泡表面活性物质气管内注入方式改进后的临床效果观察  

The observation of clinical outcomes for the drug delivery methods of pulmonary surfactant

作　　者：林世英[1] 卓燕舞[1] 林瑞凤[1] 

机构地区：[1]莆田学院附属医院儿科,福建省莆田市351100

出　　处：《中华护理教育》2012年第5期223-224,共2页Chinese Journal of Nursing Education

摘　　要：目的探讨肺泡表面活性物质安全、有效的给药方式。方法将80例确诊为新生儿呼吸窘迫综合征的早产儿随机分为试验组和对照组。试验组40例,采用5.5号头皮针直接从气管导管外壁刺入注药。对照组40例,按传统方法,分开气管导管与呼吸囊,分3个体位将药物直接从气管导管内注入。比较两组早产儿用药过程中的血氧饱和度(SpO2)、心率、口周发绀、药物反流、机械通气时间等情况。结果试验组的SpO2、心率、口周发绀、药物反流等情况好于对照组(P<0.01)。结论改进后的注药方式更有利于药物的有效利用,减少药物浪费,利于患儿生命体征的稳定,缩短机械通气时间。Objective To investigate the safe and effective drug delivery methods of pulmonary surfactant. Methods Eighty cases of premature infants with neonatal respiratory distress syndrome were randomly divided into two groups,the observation group（40 cases） and the control group（40 cases）. In the observation group,the tracheal tube was penetrated directly by 5.5 scalp needle then injected. In the control group,according to the traditional method,the tracheal catheter was separated from the breathing bag. The pulmonary surfactant was instilled directly to intratracheal catheter in three positions. The SpO2 （oxygen saturation）, heart rate, perioral blue, drug reflux, and duration of mechanical ventilation of the premature infants were compared between the two groups. Results The conditions of SpO2,heart rate,perioral blue,and drug reflux of the premature infants in the observation group were significantly better than the control group（P〈0.01）. Conclusion The improved injection method is more conducive to the effective utilization of medicine,reducing the medicine waste,the stabilization of the vital signs ,and shorten the mechanical ventilation time.

关 键 词：早产 呼吸窘迫综合征 肺泡表面活性物质 新生儿 

分 类 号：R722.1[医药卫生—儿科]