DN患者血清Cys-C、尿mAlb和血小板GMP-140检测的临床意义  

Clinical Significance of Changes of Serum Cys-C,Urine mAlb and Platelet GMP-140 Levels in Patients with DN

作　　者：史秀岩[1,2] 肖厚勤[2] 朱忠华[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院肾内科,430022 [2]湖北医药学院太和医院肾内科,442000

出　　处：《放射免疫学杂志》2012年第3期249-251,共3页Journal of Radioimmanology

摘　　要：目的:探讨糖尿病肾病(diabetic nephropathy,DN)患者血清Cys-C、尿mAlb和血小板GMP-140水平的变化及临床意义。方法:应用放射免疫分析、胶乳增强免疫比浊法和生化法对32例DN患者进行了Cys-C、尿mAlb和血小板GMP-140的检测,并与35名正常健康人作比较。结果:DN患者血清Cys-C和尿液Alb及血小板GMP-140水平均非常显著地高于正常人组(P<0.01),且血清Cys-C水平与尿mAlb、血小板GMP-140水平呈显著正相关(r=0.5642、0.6038,P<0.01)。结论:检测DN患者血清Cys-C、尿mAlb和血小板GMP-140水平的变化对了解病情、观察疗效和预后判断均有重要的临床价值。Objective To explore the clinical significance of changes of serum Cys-C, Urine mAlb and Platelet GMP-140 levels in patients with DN. Methods Serum Cys-C （with latex-enhanced immunoturbidimetry assay）, urine mAlb （with biochemistry） and platelet GMP-140 （with radioimmunoassay） levels were measured in 32 DN patients and 35 normal healthy controls. Results： Serum Cys-C, urine mAlb and platelet GMP-140 levels in the patients were significantly higher than those in controls （P 〈 0.01 ）. Serum Cys- C level was positively correlated with urine mAlb, platelet GMP-140 （ r = 0. 5642,0. 6038, P 〈 0.01 ）. Conclusion Detection of the changes of serum Cys-C , urine mAlb and platelet GMP-140 might be helpful to realize pathosis, therapeutic efficacy and prognosis, therefore, play an important role clinically.

关 键 词：糖尿病肾病 胱抑素C 尿微量白蛋白 血小板GMP-140 

分 类 号：R595.22[医药卫生—内科学]