MiR-203及其调控机制的研究进展  

The Research Progress of MiR-203 and its Regulation Mechanisms

作　　者：王健[1] 邹仲敏[1] 赵吉清[1] 

机构地区：[1]第三军医大学军事预防医学院毒理学研究所,重庆400038

出　　处：《现代生物医学进展》2012年第14期2743-2747,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金面上项目(31171118)

摘　　要：MicroRNA(miRNA)是一种长18-25个碱基的单链非编码RNA,其广泛参与机体众多病理、生理过程。MiR-203是一种上皮组织特异性表达的miRNA。研究发现miR-203在皮肤发育、皮肤相关疾病、上皮组织肿瘤等病理、生理过程中发挥重要调控作用。一些疾病的研究还发现了miR-203与表观遗传学机制的相互作用,而miR-203调控机制的研究集中在P63、SOCS-3及相关的信号通路等方面。MicroRNAs（miRNA） are 18-25-nucleotide,single-stranded,non-coding RNAs that participate in many pathological and physiological processes of the body.MiR-203 is a miRNA specially expressed in epithelial tissue.Researches show that miR-203 plays an important role in skin development,skin-related diseases,epithelial tumors and other pathological and physiological processes.The interaction between miR-203 and epigenetic mechanisms is also discovered in the researches on some diseases,while the researches on the regulation mechanisms of miR-203 focus on P63,SOCS-3 and related signal pathways.

关 键 词：MiR-203 调控 皮肤 

分 类 号：Q75[生物学—分子生物学]