布地奈德联合干扰素雾化吸入治疗小儿急性感染性喉炎疗效分析  

Curative Effect of Budesonide and α-interferon Inhalation in Treatment of Acute Laryngitis in Children

作　　者：施弦[1] 

机构地区：[1]湖州市中心医院,浙江湖州313000

出　　处：《浙江中医药大学学报》2012年第5期529-531,共3页Journal of Zhejiang Chinese Medical University

摘　　要：[目的]观察布地奈德混悬液联合α-干扰素雾化吸入治疗小儿急性感染性喉炎的临床疗效。[方法]将120例小儿急性感染性喉炎随机分为3组,A组为常规静脉组40例,B组为布地奈德单一雾化组40例,C组为布地奈德和a-干扰素联合雾化组40例。3组均在常规对症治疗基础上,A组加静脉用地塞米松,B组加布地奈德混悬液用空气压缩泵雾化吸入,C组布地奈德混悬液和a-干扰素联合雾化治疗,并观察疗效。[结果]在治疗急性喉炎患儿过程中,B组、C组在呼吸困难、喉鸣、声音嘶哑及咳嗽消失时间等指标中较A组缩短(P<0.05)。C组与B组相比较咳嗽、喉鸣时间缩短(P<0.05),但呼吸困难和声音嘶哑消失时间差异无显著性(P>0.05)。治疗3d时,各组比较治愈率及好转率差异无统计学意义(P>0.05)。[结论]布地奈德联合干扰素雾化与静脉应用地塞米松早期治疗小儿急性感染性喉炎效果相当,甚至在缓解症状上优于地塞米松,且无静脉应用激素的全身副作用,不良反应小,值得在门、急诊参考和选择。[ Objective ] To explore the effect of inhaled Budesonide and α-interferon on the treatment of acute laryngitis in children. [ Methods] One hundred and twenty infants with acute laryngitis were divided into 3 groups randomly.On the basis of the routine treatment,group A were additionally treated with Dexamethasone injected of vein,group B were additionally treated with Budesonide in halation,group C were additionally treated with Budesonide and α-interferon inhalation. [Results] There were significant differences inchnical symptoms （dyspnea, cough,hoarseness,laryngeal stridor） among the 3 groups and there were significant differences of cough and laryngeal stridor between groups C and B. There were no significant differences of cure and improvement rate among the 3 groups. [ Conclusions] The clinical effects of inhaled Budesonide and α-interferon are confirmed and using the Budesonide and α-interferon is safer than Dexamethasone on acute laryngitis, so it is worth to use on outpatient and emergency department.

关 键 词：急性感染性喉炎 Α-干扰素 布地奈德 雾化吸入 

分 类 号：R767.1[医药卫生—耳鼻咽喉科]