夫西地酸乳膏联合阿达帕林凝胶治疗寻常痤疮的临床观察  

Clinical Therapeutic Effect of Fusidic Acid Cream Combine Adapalene Gel for Acne Vulgaris

作　　者：龙福泉[1] 王千秋[2] 

机构地区：[1]海南省人民医院皮肤科,海南海口570102 [2]中国医学科学院北京协和医学院皮肤病研究所,江苏南京210042

出　　处：《中国皮肤性病学杂志》2012年第7期660-662,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的评价2%夫西地酸软膏联合0.1%阿达帕林凝胶治疗轻、中度寻常痤疮的临床疗效及安全性。方法寻常痤疮246例,随机分为3组,治疗组98例,采用2%夫西地酸软膏联合0.1%阿达帕林凝胶治疗;对照A组81例,采用1%克林霉素磷酸酯凝胶联合0.1%阿达帕林治疗;对照B组67例,单独使用0.1%阿达帕林凝胶治疗。均连用8周,分别在治疗后第2,4,8周末观察疗效并评价安全性。结果在治疗后第8周,治疗组有效率93.88%,与对照A组(81.48%)相比差异有统计学意义(P=0.010);治疗组Ⅲ级痤疮的有效率93.02%,与对照A组(69.70%)相比差异有统计学意义(P=0.007);疗程结束后,治疗组复发5例,复发率5.10%,远低于2个对照组。单独外用阿达帕林疗效均欠佳,且复发率较高。在治疗过程中,3组均未见明显不良反应。结论 2%夫西地酸软膏联合0.1%阿达帕林凝胶治疗轻、中度寻常痤疮具有疗效较好、复发率低、不良反应少等优点,是较理想的治疗方案。Objective To evaluate the clinical efficacy and safety of 2% fusidic acid cream and 0.1% adapalene gel in the treatment of mild and moderate acne vulgaris. Methods A total of 246 patients with mild to modcrate （Grade I -III ）acne vulgaris were enrolled and randomly divided into 3 groups： 98 cases in treatment group which were treated by 2% fusidic acid cream combined with 0.1% adapalene gel; 81 cases in control group A which were treated by 1% clindamycin phosphate gel combined with 0.1% adapalene gel; 67 cases in control group B which were treated only by 0.1% adapalene gel. All the patients recieved therapy for 8 weeks continuously and had been observed to evaluate the efficacy on the second, fourth and eighth week of treatment. Results On the eighth week of treatment, the total effective rate of treatment group was 93.88%, and there was a significant difference compared with the control group A（81.48% ,P =0.010）, meanwhile, the effective rate of treatment group in acne vulgaris with Grade ]II was 93.02% and there was also significant difference between these two groups（69.70% ,P = 0. 007 ）. After the treatment, there were 5 cases of recurrence in the treatment group and the recurrence rate was 5.10%, however, it was much lower than that of two control groups. The group treated only by 0.1% adapalene gel had poor effect and higher recurrence. All these 3 groups had not obvious side-effect during treatment. Conclusion It is an ideal therapy by using 2% fusidic acid cream comblned with 0.1% adapalene gel in the treatment of mild to moderate acne vulgaris with better effect, lower recurrence rate and less side-effect.

关 键 词：夫西地酸乳膏 阿达帕林凝胶 寻常痤疮 治疗 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]