红花注射液治疗胸部撞击后心肌挫伤的作用机制  

Mechanism of safflor injection treating myocardial contusion after chest impact

作　　者：吴卫春[1] 张丽萍[1] 黄金穗[1] 李小军[1] 雷国荣[1] 

机构地区：[1]杭州师范大学医学院附属余杭医院心胸外科,311100

出　　处：《中华创伤杂志》2012年第6期561-564,共4页Chinese Journal of Trauma

基　　金：杭州市卫生科技计划资助项目（200880111）

摘　　要：目的探讨红花注射液对撞击所致心肌挫伤的治疗作用机制。方法选取30只健康日本大耳兔，按随机数字表法分为心肌挫伤对照组（对照组）和红花注射液治疗组（红花组），每组15只。用BIM-Ⅱ型生物撞击机制备兔严重心肌挫伤模型。分别于伤前10min、伤后10，3min、1，3，6，12，24h各时相点采集两组颈总动脉血，检测血栓素A2（TXA2）、前列环素（PG12）的浓度；于伤后24h解剖观察心脏大体和显微病理改变。结果对照组伤后血浆PGI2浓度较伤前明显下降，TXA2浓度较伤前明显升高，形态学检查心肌组织损伤较重；红花组伤后血浆PGI2浓度降低幅度和TXA2浓度升高幅度较对照组均不明显，心肌组织损伤也较对照组明显减轻；血浆血栓素B2（TXB2）／6-酮-前列腺素F1a（6-Keto-PGFla）比值伤后红花组明显低于对照组（P〈0．05）。结论红花注射液对心肌挫伤有治疗作用，其机制可能与红花注射液能升高血浆PGI2浓度、降低TXA2浓度有关。Objective To investigate the mechanism of safflor injection treating myocardial con- tusion following thoracic impact. Methods Thirty healthy Japan big-ear rabbits were randomly as- signed to the myocardial contusion control group （ control group, n = 15 ） and safflor injection group （ saf- flor group, n = 15 ）. The rabbits with severe myocardial contusion were induced by BIM- Ⅱ HorizontaI Bioimpact Machine. Blood samples were taken from common carotid artery of both groups to measure the levels of plasma thromboxance A2 （TXA2 ） and prostaglandin I2 （PGI2 ） at 10 minutes before impact and at 10 minutes, 30 minutes, 1, 3, 6, 12 and 24 hours after impact. Rabbits were dissected to observe the gross and micropathological changes of the heart at 24 hours after impact. Results The control group showed a distinct falling of plasma PGI2 concentration and a significant increase of plasma TXA2 concentra- tion in the early period after severe myocardial contusion. The morphological observation revealed severe myocardial tissue injury as well. However, the safflor group showed insignificant variation pertaining to the reduction of plasma PGI2 concentration and increase of plasma TXA2 concentration, but obvious alleviation of myocardial tissue injury, as compared with the control group. Meanwhile, the ratio of TXB2 to 6- Keto- prostaglandin Fla （6-Keto-PGFla） in the safflor group was lower than that of the control group （P 〈 0.05 ）. Conclusion Safflor injection has therapeutic effect on myocardial contusion by elevating the con- centration of plasma PGI2 and decreasing the concentration of plasma TXA2 in the early period after severe myocardial contusion.

关 键 词：胸部损伤 心肌 红花注射液 

分 类 号：R285.5[医药卫生—中药学]