骨髓增殖性疾病转化为急性髓系白血病后细胞免疫表型的变化  

Changes of Cell Immunophenotypes after Transformation from Myeloproliferative Disorders into Acute Myeloid Leukemia

作　　者：陈雪[1] 王谷云[2] 邢海洲[3] 孙玉华[3] 胡旸[3] 田正芹[3] 陈艳[3] 张英[3] 姚红霞[2] 朱平[3] 

机构地区：[1]北京航天总医院血液肿瘤研究所,北京100076 [2]海南省人民医院血液科,海南海口570311 [3]北京大学第一医院血液研究室,北京100034

出　　处：《中国实验血液学杂志》2012年第3期636-641,共6页Journal of Experimental Hematology

基　　金：国家863计划资助项目(编号2008AA062503);首都特色临床医学技术发展基金(编号Z080507030808010)

摘　　要：一些骨髓增殖性疾病(MPD)病例有可能转化为急性髓系白血病(AML),但是迄今尚未观察到体内MPD细胞转化为AML细胞的分化过程。本研究旨在揭示这一分化过程。采用流式细胞术分析了2例MPD短期内转为AML患者骨髓分化细胞的免疫表型特征。研究结果表明,体内发展相对缓慢的MPD增殖细胞演化为迅速扩增的急性白血病细胞时,存在不同分化阶段的亚克隆。结论:了解MPD急变过程将有助于早期诊断和治疗MPD转化的急性白血病。Some cases of myeloproliferative disorders（MPD） could be transformed into acute myeloid leukemia（AML）,but the cell differentiation process of MPD into AML has not yet been observed in vivo.This study was aimed to reveal this differentiation process.The flow cytometry was used to analyse the immunophenotype of differentiated cells of 2 MPD cases who developed into AML in a short time.The reports showed that the different MPD-AML subclones are presented when the MPD cells that proliferate slowly in vivo become the AML blast cells that proliferate rapidly.It is concluded that understanding the process of MPD crisis will help the MPD-AML early diagnosis and treatment.

关 键 词：骨髓增殖性疾病 急性髓系白血病 细胞免疫表型 

分 类 号：R551.3[医药卫生—血液循环系统疾病] R733.3[医药卫生—内科学]