转化生长因子-β1及其受体在免疫性血小板减少性紫癜症患者中的表达及意义  

Expression of Transforming Growth Factor-β1 and Its Receptors in Peripheral Blood of Patients with Immune Thrombocytopenic Purpura

作　　者：方治[1] 张翼鷟[2] 蔡挺[1] 李克强[1] 余静[1] 罗央清[1] 赵海丰[2] 

机构地区：[1]宁波市第二医院血液肿瘤科,浙江宁波315010 [2]天津医科大学附属肿瘤医院血液肿瘤科,天津300060

出　　处：《中国实验血液学杂志》2012年第3期664-666,共3页Journal of Experimental Hematology

基　　金：宁波市科技计划项目(编号2011A610029);国家自然科学基金项目(编号81100337)

摘　　要：本研究通过检测外周血转化生长因子(TGF-β1)及其受体((TGF-βR)的表达探讨其在免疫性血小板减少性紫癜症(ITP)发病中的作用机制。以ITP患者为研究对象,健康人为对照,通过实时PCR方法检测外周血中TGF-β1及其受体(TGF-βRⅠ、TGF-βRⅡ和TGF-βRⅢ)的表达量,分析两组之间的差异。结果表明,ITP患者组TGF-β1和TGF-βRⅡmRNA的表达明显高于正常对照组,差异有统计学意义,而TGF-βRⅠmRNA的表达明显低于正常对照组,差异有统计学意义。TGF-βRⅢmRNA的表达在两组间无统计学差异。结论:TGF-β1及其受体TGF-βRⅠ和TGF-βRⅡ在ITP患者中表达异常,表明TGF-β1信号通路在ITP患者发病中可能具有一定的作用。This study was purposed to detect the expression of transforming growth factor β1（TGF-β1） and its receptors（TGF-βR） and to investigate their roles in pathogenesis of immune thrombocytopenic purpura（ITP）.The expressions of TGF-β1 and their receptors TGF-βRⅠ,TGF-βRⅡ and TGF-βRⅢ in the peripheral blood of patients with ITP and healthy persons were detected by the real-time PCR,and differences of their expression levels were analysed.The results showed that the expression of TGF-β1 and TGF-βRⅡ mRNA in ITP patients was significantly higher than that in the healthy controls,while the TGF-βRⅠ mRNA expression in ITP patient was significantly lower than that in the controls.The expression of TGF-βRⅢ was not statistically different between the two groups.It is concluded that TGF-β1 and its receptors including TGF-βRⅠ and TGF-βRⅡ express abnormally in the peripheral blood of ITP patients,which suggests that the TGF-β signaling pathway probably play a vital role in the pathogenesis of the ITP.

关 键 词：免疫性血小板减少性紫癜症 转化生长因子-Β1 转化生长因子-Β受体 

分 类 号：R554.6[医药卫生—血液循环系统疾病]