免疫细胞衰老的研究进展  

Research Progress on Immunocyte Senescence——Review

作　　者：杨波[1] 迟小华[2] 卢学春[1] 脱帅[3] 张峰[4] 张文英[1] 脱朝伟[3] 韩为东[5] 姚善谦[1] 

机构地区：[1]解放军总医院老年血液科,北京100853 [2]解放军第二炮兵总医院药剂科,北京100800 [3]解放军第202医院医务处,辽宁沈阳110003 [4]中国科学院北京基因组研究所,北京100029 [5]解放军总医院基础研究所免疫室,北京100853

出　　处：《中国实验血液学杂志》2012年第3期782-787,共6页Journal of Experimental Hematology

基　　金：国家自然科学基金资助项目(编号30772597;30873086;81172986);解放军总医院科技创新苗圃基金资助项目(11KMM24)

摘　　要：免疫系统随着年龄的增加而功能退化,出现免疫衰老。人的免疫系统可以分为遗传性/先天性和种系新生两大部分。前者以单核细胞、自然杀伤细胞和树突状细胞为代表;后者以获得性免疫(B和T淋巴细胞)为代表。在衰老过程中,这两部分均以不同方式出现损伤,但先天性免疫保留相对完好,而获得性免疫的改变具有较强的年龄依赖性。免疫衰老与老年人群肿瘤多发性、感染的易感性和疫苗的低效性密切相关。本文就免疫系统随年龄衰老的特征进行综述。The function of immune system degenerates in an aging-dependent manner and this results in immunosenescence.Human immune system includes two parts： genetic/innate immunity and adaptive immunity.The former is involved in monocytes,nature killer cells,and dendritic cells,the later is involved in acquired B and T lymphocytes.During the aging of immunity system,the both parts of immunity are damaged to some degree.Generally,innate immunity seems well-retained and the acquired immunity is degenerative seriously with aging.Immunocyte senescence is closely related to the elderly decreased ability to control infectious disease,cancer and to their generally poor response to vaccination.This review summarized the research progress on immunosenescence characteristics in aged phase.

关 键 词：免疫细胞 免疫衰老 淋巴细胞 肿瘤 

分 类 号：R392.12[医药卫生—免疫学]