PPARD-87T〉C与PPARA和PPARG单核苷酸多态性之间的交互作用对腹型肥胖的影响  

Effects of PPARD-87T 〉 C and interactions with single nucleotide polymorphisms in PPARA and PPARG on abdominal obesity

作　　者：丁一[1] 郭志荣[1] 武鸣[2] 陈秋[3] 周正元[4] 俞浩[2] 张丽君[1] 刘景超[1] 骆文书[1] 

机构地区：[1]苏州大学医学部公共卫生学院流行病与卫生统计教研室,215123 [2]江苏省疾病预防控制中心慢病科 [3]苏州大学医学部放射生物学教研室 [4]江苏省常熟市疾病预防控制中心

出　　处：《中华医学杂志》2012年第22期1517-1521,共5页National Medical Journal of China

基　　金：卫生部科学研究基金（WKJ2004-2-014）

摘　　要：目的探讨过氧化物酶体增殖物激活受体（PPAR）10个单核苷酸多态性（SNP）与腹型肥胖的关联以及多个SNP的交互作用对腹型肥胖的影响。方法对820名研究对象进行PPAR10个SNP的检测。分析SNP与腹型肥胖的关联及10个SNP的基因一基因交互作用。结果与TT（野生型）基因型携带者相比，rs2016520（-87T〉C）位点的（TC＋CC）基因型携带者发生腹型肥胖的风险显著降低（OR=0．68，95％C／0．52-0．90，P=0．005）。调整性别、年龄、吸烟、饮酒、高脂饮食和低纤维饮食，广义多因子降维法发现3阶（rs2016520，rs9794和rs1805192）和5阶交互作用模型（rs135539、rs2016520、rs10865710、rs1805192和rs709158）差异有统计学意义。结论PPARD的rs2016520多态性在腹型肥胖的发生中有主导效应，单基因关联分析里不显示主效应的SNP在调节腹型肥胖的分子机制中也发挥交互效应。Objective To examine the main effect of 10 single nucleotide polymorphisms （SNPs） in contribution to abdominal obesity and study whether there is an interaction in the 10 SNPs in the cause of abdominal obesity. Methods A total of 820 subjects were randomly selected and no individual was related. Individual polymorphism and interactions were available for analyses. Results C allele carrier （ CC ＋ TC） was significantly higher than that of TY genotype （ OR （95% CI） =0. 68（0. 52 -0. 90）, P =0. 005）. A 5- dimension gene-to-gene interaction model existed among rs135539, rs2016520, rs10865710, rs1805192 and rs709158 on the incidences of abdominal obesity. Conclusions The C allele in rs2016520 is significantly associated with a lower rate of abdominal obesity. And there is an interaction among rs2016520, rs135539, rs10865710, rs1805192 and rs709158 on the incidences of abdominal obesity.

关 键 词：肥胖 过氧化物酶体增殖物激活受体 基因 多态性 交互作用 

分 类 号：R589.2[医药卫生—内分泌]