MR扩散张量成像在前列腺癌诊断中的价值  

Diffusion tensor imaging of the prostate cancer

作　　者：夏国金[1] 龚洪翰[1] 曾献军[1] 姜建[1] 周福庆[1] 胡珍珍[1] 

机构地区：[1]南昌大学第一附属医院影像科,330006

出　　处：《中华放射学杂志》2012年第6期526-528,共3页Chinese Journal of Radiology

摘　　要：目的探讨MRDTI在前列腺癌诊断中的价值。方法回顾性分析2009年10月至2010年12月期间，临床怀疑为前列腺癌且行MR常规检查及DTI扫描的44例患者的资料。病理证实为前列腺癌16例、良性前列腺增生28例。采用t检验比较前列腺癌、良性前列腺增生患者问各向异性分数（FA）值及ADC值的差异，采用ROC曲线分析FA值及ADC值对前列腺癌诊断效能，并初步确定前列腺癌FA值及ADC值诊断阈值。结果前列腺癌区和良性前列腺增生的FA值分别为0．308±0．084和0．203±0．029，ADC值分别为（0．883±0．192）×10^-3和（1．408±0．130）×10^-3mm^2／s，差异均有统计学意义（t值分别为4．833和10．779，P值均〈0．01）。ROC曲线上，ADC曲线下面积为0．996（95％可信区间为0．984～1．007），FA值曲线下面积为0．904（95％可信区间为0．812-0．996），FA值联合ADC值的曲线下面积为0．996（95％可信区间为0．984-1．007）。ADC值阈值为0．725×10^-3mm^2／s，敏感度为100．0％，特异度为96．0％；FA值阈值为0．311，敏感度为100．0％，特异度为68．7％。结论DTI成像能为前列腺癌诊断及鉴别诊断提供有价值的信息，有助于提高对前列腺癌的诊断能力。Objective To explore the diagnostic value of DTI for prostate cancer. Methods From October 2009 to December 2010, 44 patients suspected of prostate cancer received MRI and DTI. The data of MRI and DTI were analyzed retrospectively. By histopathology, prostate cancer was proved in 16 patients, and benign prostatic hyperplasia （BPH） was proved in 28 patients. Differences in ADC and FA values between prostate cancer and BPH were compared by independent samples t test. Diagnostic accuracy of FA value and ADC value for prostate cancer was analyzed by using ROC curve, and the diagnostic threshold of FA value and ADC value for prostate cancer was determined. Results The mean FA value of the tumor regions and BPH were 0. 308 ± 0. 084 and 0. 203 ± 0. 029, respectively. The mean ADC value of the tumor regions and BPH were （0. 883 ± 0. 192） ×10^-3 mm^2/s and （1. 408 ± 0. 130） × 10^-3 mm^2/s, respectively. There were statistically significant differences in ADC and FA values between tumor regions and BPH （t values were 4. 833 and 10. 779 respectively, P〈0. 01 ）. The ADC value area under curve of ROC was 0. 996 （95% CI was 0. 984 to 1. 007） ; the FA value area under curve of ROC was 0. 904 （95% CI was 0. 812 to 0. 996） ; Combined the FA and ADC value area under curve of ROC is 0. 996（95% CI was 0. 984 to 1. 007 ） ; Using the ADC value of 0. 725× 10 ^-3 mm^2/s as the ROC cut off point, the diagnostic sensitivity and specificity were 100.0% and 96. 0%, respectively; Using the FA value of 0. 311 as the ROC cut off point, the diagnostic sensitivity and specificity was 100. 0% and 68.7%, respectively. Conclusion DTI imaging can provide valuable information for prostate cancer diagnosis and differential diagnosis, and improve the diagnosis abilitv of prostate cancer.

关 键 词：前列腺肿瘤 前列腺增生 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]